Evidence map›Paper›PMID 21105687›Full record

ArticleThe Journal of organic chemistry2010

Synthesis of 7-aza-5-deazapurine analogues via copper(I)-catalyzed hydroamination of alkynes and 1-iodoalkynes.

Larissa B Krasnova, Jason E Hein, Valery V Fokin

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Larissa B KrasnovaDepartment of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
Jason E Hein
Valery V Fokin

Funding

STRUCTURE-BASED MECHANISMS FOR RESISTANCE TO PROTEASE INHIBITORSP01GM083658 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI OLSON, ARTHUR J. · 2008 to 2012
$9.6M
Carbon-Heteroatom Bond-Forming ReactionsR01GM087620 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI FOKIN, VALERY V · 2009 to 2013
$1.8M
NIGMS NIH HHS GM087620NIGMS NIH HHS P01 GM083658NIGMS NIH HHS R01 GM087620
6 · The paper itself

Abstract

A new method for the synthesis of dihydroimidazo[1,2-a][1,3,5]triazin-4(6H)-ones via copper(I)-catalyzed hydroamination was developed. In addition, for the first time, iodoalkynes were shown to participate in the copper(I)-catalyzed intramolecular hydroamination reaction with exclusive formation of E-isomers.

Indexed as

AlkynesAminationAza CompoundsCatalysisCopperHydrocarbons, IodinatedIsomerismMolecular StructurePurines1H-imidazo(4,5-b)pyridineAlkynesAza CompoundsCopperHydrocarbons, IodinatedPurines

Identifiers

PMID21105687
PMCPMC3025312

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.