ArticleJournal of the American Chemical Society2010
Chemical probes that selectively recognize the earliest Aβ oligomers in complex mixtures.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Prediction of fibril formation by early-stage amyloid peptide aggregation.Journal of pharmaceutical analysis · 2020Article
- Multivalent Polymer-Peptide Conjugates-A General Platform for Inhibiting Amyloid Beta Peptide Aggregation.ACS macro letters · 2019Article
- Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.Science translational medicine · 2017Article
- How accurate are your simulations? Effects of confined aqueous volume and AMBER FF99SB and CHARMM22/CMAP force field parameters on structural ensembles of intrinsically disordered proteins: Amyloid-βIntrinsically disordered proteins · 2017Article
- SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer´s disease: appealing for ESI-IM-MS.Scientific reports · 2015Article
- Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes.Scientific reports · 2015Article
- Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at critical concentrations of IAPP.The journal of physical chemistry. B · 2015Article
- Aβ42-binding peptoids as amyloid aggregation inhibitors and detection ligands.ACS chemical neuroscience · 2013Article
- Facile methodology for monitoring amyloid-β fibrillization.ACS chemical neuroscience · 2012Article
- Article
- Insight into amyloid structure using chemical probes.Chemical biology & drug design · 2011Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Alzheimer's disease (AD) is characterized by the self-assembly of amyloid beta (Aβ) peptides. Recent models implicate some of the earliest Aβ oligomers, such as trimers and tetramers, in disease. However, the roles of these structures remain uncertain, in part, because selective probes of their formation are not available. Toward that goal, we generated bivalent versions of the known Aβ ligand, the pentapeptide KLVFF. We found that compounds containing sufficiently long linkers (∼19 to 24 Å) recognized primarily Aβ trimers and tetramers, with little binding to either monomer or higher order structures. These compounds might be useful probes for early Aβ oligomers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.