ArticleWorld journal of gastroenterology2010
Chronic stress sensitizes rats to pancreatitis induced by cerulein: role of TNF-α.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Aldosterone induced by chronic stress promotes pancreatic steatosis in young male rats.Cell and tissue research · 2026Article
- L-arginine-induced chronic pancreatitis in mice: Evaluating effects of pirfenidone and simvastatin.World journal of gastrointestinal pharmacology and therapeutics · 2025Article
- Assessing the therapeutic potential of Tirzepatide in modulating inflammatory responses and mitigating acute pancreatitis.Animal models and experimental medicine · 2025Article
- Combination of Botanicals and Mindfulness Meditation for the Treatment of Chronic Pancreatitis: A Case Report.Journal of chiropractic medicine · 2025Article
- CCK regulates osteogenic differentiation through TNFα/NF-κB in peri-implantitis.The Journal of international medical research · 2022Article
- Melatonin Modulates the Antioxidant Defenses and the Expression of Proinflammatory Mediators in Pancreatic Stellate Cells Subjected to Hypoxia.Antioxidants (Basel, Switzerland) · 2021Article
- The counteracting effects of (-)-Epigallocatechin-3-Gallate on the immobilization stress-induced adverse reactions in rat pancreas.Cell stress & chaperones · 2021Article
- Sex differences impact the pancreatic response to chronic immobilization stress in rats.Cell stress & chaperones · 2021Article
- Evaluation of the immune status of peripheral blood monocytes from dairy cows during the periparturition period.The Journal of reproduction and development · 2019Article
- Impact of chronic exercise on counteracting chronic stress-induced functional and morphological pancreatic changes in male albino rats.Cell stress & chaperones · 2019Article
- Endogenous glucagon-like peptide- 1 and 2 are essential for regeneration after acute intestinal injury in mice.PloS one · 2018Article
- Targeting NK-1 Receptors to Prevent and Treat Pancreatic Cancer: a New Therapeutic Approach.Cancers · 2015Review
- Immune-modulating therapy in acute pancreatitis: fact or fiction.World journal of gastroenterology · 2014Review
- Rutin modulates ASC expression in NLRP3 inflammasome: a study in alcohol and cerulein-induced rat model of pancreatitis.Molecular and cellular biochemistry · 2014Article
- Acute pancreatitis: the stress factor.World journal of gastroenterology · 2014Review
- Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats.Journal of biomarkers · 2013Article
- Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate chronic stress as a susceptibility factor for developing pancreatitis, as well as tumor necrosis factor-α (TNF-α) as a putative sensitizer.
methodsRat pancreatic acini were used to analyze the influence of TNF-α on submaximal (50 pmol/L) cholecystokinin (CCK) stimulation. Chronic restraint (4 h every day for 21 d) was used to evaluate the effects of submaximal (0.2 μg/kg per hour) cerulein stimulation on chronically stressed rats.
resultsIn vitro exposure of pancreatic acini to TNF-α disorganized the actin cytoskeleton. This was further increased by TNF-α/CCK treatment, which additionally reduced amylase secretion, and increased trypsin and nuclear factor-κB activities in a protein-kinase-C δ and ε-dependent manner. TNF-α/CCK also enhanced caspases' activity and lactate dehydrogenase release, induced ATP loss, and augmented the ADP/ATP ratio. In vivo, rats under chronic restraint exhibited elevated serum and pancreatic TNF-α levels. Serum, pancreatic, and lung inflammatory parameters, as well as caspases'activity in pancreatic and lung tissue, were substantially enhanced in stressed/cerulein-treated rats, which also experienced tissues' ATP loss and greater ADP/ATP ratios. Histological examination revealed that stressed/cerulein-treated animals developed abundant pancreatic and lung edema, hemorrhage and leukocyte infiltrate, and pancreatic necrosis. Pancreatitis severity was greatly decreased by treating animals with an anti-TNF-α-antibody, which diminished all inflammatory parameters, histopathological scores, and apoptotic/necrotic markers in stressed/cerulein-treated rats.
conclusionIn rats, chronic stress increases susceptibility for developing pancreatitis, which involves TNF-α sensitization of pancreatic acinar cells to undergo injury by physiological cerulein stimulation.
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