ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2011
Impact of ischemia on left ventricular dyssynchrony by phase analysis of gated single photon emission computed tomography myocardial perfusion imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic significance of phase analysis using SPECT myocardial perfusion imaging in heart failure: a systematic review and meta-analysis.The international journal of cardiovascular imaging · 2025Pooled it
- Prognostic value of left ventricular mechanical dyssynchrony indices derived from gated myocardial perfusion SPECT in coronary artery disease: a systematic review and meta-analysis.Annals of nuclear medicine · 2024Pooled it
- Value of intraventricular dyssynchrony assessment by gated-SPECT myocardial perfusion imaging in the management of heart failure patients undergoing cardiac resynchronization therapy (VISION-CRT).Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Trial
- Incremental prognostic value of stress phase entropy over standard PET myocardial perfusion imaging variables.European journal of nuclear medicine and molecular imaging · 2023Article
- Left ventricular mechanical dyssnchrony: A potential new marker for 3-vessel CAD.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Diagnosis, performance and added value of assessing ventricular dyssynchrony by phase analysis in patients with three-vessel disease: A single-center cross-sectional study in Mexico.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prognostic value of left ventricular mechanical dyssynchrony induced by exercise stress in patients with normal myocardial perfusion single-photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Normal and Range Value Evaluations Using Heart Risk View-Function Based on the Japanese Societyof Nuclear Medicine Working Group Database.Annals of nuclear cardiology · 2022Article
- Myocardial ischemia and previous infarction contribute to left ventricular dyssynchrony in patients with coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Prognostic Value of Phase Analysis for Predicting Adverse Cardiac Events Beyond Conventional Single-Photon Emission Computed Tomography Variables: Results From the REFINE SPECT Registry.Circulation. Cardiovascular imaging · 2021Observational
- Left ventricular mechanical dyssynchrony in patients with chest pain and normal epicardial coronary arteries.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Are SPECT MPI measures of dyssynchrony dyssynchronous?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Auxiliary ischemic markers, the role of left ventricular dyssynchrony.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Left ventricular dyssynchrony and abnormalities in wall motion, assessed by gated-SPECT as ischemic auxiliary markers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Observational
- Is myocardial viability related to left ventricular dyssynchrony?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Could myocardial viability be related to left ventricular dyssynchrony? Simultaneous evaluation by gated SPECT-MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Left ventricular mechanical dyssynchrony for CAD diagnosis: Does it have incremental clinical values?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Myocardial stunning by gated SPECT: An old tool reinvented in a stunning turn.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Phase analysis single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) detects dyssynchrony in myocardial scar and increases specificity of MPI.EJNMMI research · 2019Article
- Myocardial stunning-induced left ventricular dyssynchrony on gated single-photon emission computed tomography myocardial perfusion imaging.Nuclear medicine communications · 2018Article
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Authors and funding
4 authors.
Funding
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Abstract
backgroundThere is increasing awareness of the value of phase analysis of gated tomographic myocardial perfusion imaging in assessing left ventricular (LV) dyssynchrony. A concern repeatedly raised in many studies is whether reversible defects in the stress images "ischemia" could affect the phase-derived standard deviation and bandwidth, the two commonly used dyssynchrony indices. We hypothesized that the stress and rest images should provide comparable information because the images are acquired 1 hour after the tracer injection. METHODS AND
resultsWe studied two groups of patients with normal LV ejection fraction and no fixed perfusion defects. In group-1 (N = 20), the patients had reversible perfusion defects involving > 10% of the LV myocardium and in group-2 (N = 20), the patients had normal images. All patients underwent stress/rest-gated single photon emission computed tomography sestamibi imaging (the stress study was acquired with the lower dose) between January and March 2010. Patients with left bundle branch block or ventricular pacing were excluded. The patients in group-1 had a mean age of 61 ± 9 years, 65% were men, 75% Caucasians, and 70% had known prior coronary artery disease. The size of the reversible perfusion defect was 20 ± 13% (range 11%-50%) of the LV myocardium. The rest and stress phase-derived standard deviation (16 ± 6° vs 18 ± 8° and 16 ± 7° vs. 19 ± 6°) and the rest and stress bandwidth (42 ± 14° vs 46 ± 16° and 45 ± 17° vs 52 ± 12°), respectively, (P = NS for all) were similar in the two groups. The change (stress-rest) in standard deviation and bandwidth in groups 1 and 2 were not statistically significant (0.2 ± 3.1° vs 1.4 ± 4.7°, and 2 ± 13° vs 5 ± 13°, respectively, P = NS). There was no significant change from rest to stress in the standard deviation and the bandwidth in group-1 (P = .8 and .4, respectively) and group-2 (P = .2 and .08, respectively). There was no correlation between the size of the reversible perfusion defect and the change in phase standard deviation or bandwidth (r = 0.07 and 0.12, respectively, P = NS).
conclusionsThe presence of even a large reversible perfusion defect does not alter the indices of mechanical dyssynchrony by phase analysis. Further, comparable information is obtained whether using a low dose or a high dose of the radiotracer.
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