ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2011
Semi-automated algorithm for calculating heart-to-mediastinum ratio in cardiac Iodine-123 MIBG imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
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- Multicenter development and validation of a probability-based model to diagnose Lewy body disease using ¹²³I-meta-iodobenzylguanidine.European journal of nuclear medicine and molecular imaging · 2026Article
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- Diagnostic Sensitivity and Symptomatic Relevance of Dopamine Transporter Imaging and Myocardial Sympathetic Scintigraphy in Patients with Dementia with Lewy Bodies.Journal of Alzheimer's disease : JAD · 2024Article
- Cardiac Sympathetic Nerve Function in Patients with Severe Aortic Stenosis Prior and After Transcatheter Aortic Valve Implantation: Evaluation by 5-Year Risk Model.Annals of nuclear cardiology · 2024Article
- Vagus Nerve Ultrasonography Helps Distinguish Multiple System Atrophy from Other Parkinsonian Syndromes.Movement disorders clinical practice · 2023Article
- Cardiac sympathetic activity and relationship to cardiac events and left ventricular reverse remodeling in patients with non-ischemic dilated cardiomyopathy.Annals of nuclear medicine · 2023Article
- Machine learning-based prediction of conversion coefficients for I-123 metaiodobenzylguanidine heart-to-mediastinum ratio.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Early Effect of Transcatheter Mitral Valve Repair on Cardiac Sympathetic Nerve Activity.Structural heart : the journal of the Heart Team · 2023Article
- Left ventricular hypertrophy as a predictor of cardiovascular outcomes after transcatheter aortic valve replacement.ESC heart failure · 2023Observational
- Comparison of Taiwanese and European Calibration Factors for Heart-to-Mediastinum Ratio in MulticenterAnnals of nuclear cardiology · 2023Article
- Three-Dimensional Heart Segmentation and Absolute Quantitation of CardiacAnnals of nuclear cardiology · 2023Article
- Phantom-Based Standardization Method forAnnals of nuclear cardiology · 2023Article
- Serial changes in cardiac sympathetic nervous function after transcatheter aortic valve replacement: A prospective observational study usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Observational
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Authors and funding
8 authors.
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Abstract
backgroundWe have developed novel software for semi-automatically measuring heart-to-mediastinum (H/M) ratio in cardiac Iodine-123 (¹²³I)-labeled meta-iodobenzylguanidine (MIBG) imaging. Our aim is to improve the reproducibility of the H/M ratio using the semi-automated method as opposed to the manual method. METHODS AND
resultsThe software algorithm automatically determined the mediastinal region of interest (ROI) using information from ¹²³I-MIBG uptake of the heart, lung, liver, and thyroid after a cardiac circular ROI was manually set. A total of 37 patients who underwent both early and delayed ¹²³I-MIBG imaging was retrospectively selected. The heart-to-mediastinum (H/M) ratios were calculated by both semi-automated and manual methods and assessed for the intra- and inter-observer variability. All H/M ratios were classified into three groups: normal, slight abnormality, and severe abnormality. The H/M ratios with the new method were higher than those obtained manually (P < .001). In the test-retest reliability, the intra-class correlation coefficient from the semi-automated method showed excellent reproducibility for early (0.99) and delayed (0.99) imaging. The Bland-Altman plots demonstrated better agreement using the semi-automated method (a range of 95% limits -0.11 to 0.10) than that in the manual method (-0.34 to 0.27). The inter-observer agreement was also good using the semi-automated method (κ = 0.866).
conclusionsThe H/M ratio using the semi-automated method showed high reproducibility in both early and delayed imaging.
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