Evidence map›Paper›PMID 21104347›Full record

ReviewCurrent allergy and asthma reports2011

New developments in the use of histamine and histamine receptors.

Craig Smuda, Paul J Bryce

Open access · greenAbstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Importance of mast cell histamine secretion in IgG-mediated systemic anaphylaxis.The Journal of allergy and clinical immunology · 2025
    Article
  5. Therapeutic Targets in Allergic Conjunctivitis.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  6. Article
  7. Comparative Study of Chemical Stability of Two HJournal of analytical methods in chemistry · 2019
    Article
  8. Review
  9. Novel challenges for the allergist.Clinical reviews in allergy & immunology · 2011
    Article
  10. Antihistamines in ocular allergy: are they all created equal?Current allergy and asthma reports · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Craig SmudaDepartment of Medicine/Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, McGaw M315, 240 E. Huron St., Chicago, IL 60611, USA.
Paul J Bryce
Northwestern University · US

Funding

Regulation of T cell migration by histamineR01AI076456 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HULSE, KATHRYN ELIZABETH · 2008 to 2017
$3.9M
NIAID NIH HHS R01 AI076456
6 · The paper itself

Abstract

Histamine and the histamine receptors are important regulators of a plethora of biological processes, including immediate hypersensitivity reactions and acid secretion in the stomach. In these roles, antihistamines have found widespread therapeutic applications, while the last receptor to be discovered, the H4 histamine receptor, has become a major target of novel therapeutics. Recent studies involving human genetic variance and the development of mice lacking specific receptors or the ability to generate histamine have shown roles for the histamine pathway that extend well beyond the established roles. These include identification of previously unappreciated mechanisms through which histamine regulates inflammation in allergy, as well as roles in autoimmunity, infection, and pain. As a result, antihistamines may have wider applications in the future than previously predicted.

Indexed as

Genetic VariationHistamineHypersensitivityReceptors, HistamineAnimalsHistamine AntagonistsHumansInflammationMiceHistamineHistamine AntagonistsReceptors, Histamine

Identifiers

PMID21104347
PMCPMC3068859
OpenAlexW2019905508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.