ArticleInflammation2011
Efficacy of Bacopa monniera (L.) Wettst in alleviating lysosomal instability in adjuvant-induced arthritis in rats.
Article in Inflammation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Ginseng extract improves synaptic resiliency: A key factor for healthy cognitive aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Balancing the Cellular Inflammatory-Homeostatic Axis Through Natural Ingredient Supplementation.Nutrients · 2025Article
- The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain.Journal of ethnopharmacology · 2017Article
- Majoon ushba, a polyherbal compound, suppresses pro-inflammatory mediators and RANKL expression via modulating NFкB and MAPKs signaling pathways in fibroblast-like synoviocytes from adjuvant-induced arthritic rats.Immunologic research · 2016Article
- Medicinal plants with potential anti-arthritic activity.Journal of intercultural ethnopharmacologyArticle
- Scientific validation of anti-arthritic effect of Kashayams - A polyherbal formulation in collagen induced arthritic rats.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was aimed to assess the effect of Bacopa monniera extract against lysosomal instability during adjuvant-induced arthritis in rats. B. monniera extract was administered orally at a dose of 100 mg/kg body weight for 30 days to the experimental rats after the induction of adjuvant arthritis. The ability of B. monniera extract to stabilize lysosomal enzyme activities in the cartilage of control and experimental rats was done by monitoring the activities of pathophysiological enzymes such as β-glucuronidase, β-glucosaminidase, cathepsin D, hyaluronidase, collagenase and the level of protein bound carbohydrates and glycosaminoglycans (GAGs) in arthritic rats. B. monniera extract supplementation significantly inhibited lysosomal instability in different tissues studies and improved the level of glycoproteins in synovial effusate and GAG in the cartilage. To evaluate whether anti-inflammatory property of B. monniera extract was due to lysosomal stability and GAG protection, purified chloroform fraction of B. monniera (CF) was assayed for its role to modulate interleukin-6 (IL-6) expression and prostaglandin E2 (PGE2) production. Administration of CF (50 mg/kg) to arthritic rats significantly downregulated the expression of IL-6 in blood mononuclear cells and PGE2 levels in cartilage tissue. The possible mechanism of action of the B. monniera extract may be through its stabilizing action on lysosomal membranes and hence the decrease in spread of inflammation.
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