ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2011
Expression analysis of the early chemokine response 4 h after in vitro traumatic brain injury.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- The Role of Nanotechnology in Understanding the Pathophysiology of Traumatic Brain Injury.Central nervous system agents in medicinal chemistry · 2025Review
- Neutrophils in traumatic brain injury (TBI): friend or foe?Journal of neuroinflammation · 2018Review
- Analysis of the Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Traumatic Brain and Spinal Cord Injury: Insight into Recent Advances in Actions of Neurochemokine Agents.Molecular neurobiology · 2017Review
- Loss of PAFR prevents neuroinflammation and brain dysfunction after traumatic brain injury.Scientific reports · 2017Article
- Acute death of astrocytes in blast-exposed rat organotypic hippocampal slice cultures.PloS one · 2017Article
- Bilateral gene interaction hierarchy analysis of the cell death gene response emphasizes the significance of cell cycle genes following unilateral traumatic brain injury.BMC genomics · 2016Article
- Acute Response of the Hippocampal Transcriptome Following Mild Traumatic Brain Injury After Controlled Cortical Impact in the Rat.Journal of molecular neuroscience : MN · 2015Article
- What's New in Traumatic Brain Injury: Update on Tracking, Monitoring and Treatment.International journal of molecular sciences · 2015Review
- A systems biology strategy to identify molecular mechanisms of action and protein indicators of traumatic brain injury.Journal of neuroscience research · 2015Article
- Effects of blast overpressure on neurons and glial cells in rat organotypic hippocampal slice cultures.Frontiers in neurology · 2015Article
- In vivo microdialysis sampling of cytokines from rat hippocampus: comparison of cannula implantation procedures.ACS chemical neuroscience · 2013Article
- Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response.BMC genomics · 2013Article
- Guilty molecules, guilty minds? The conflicting roles of the innate immune response to traumatic brain injury.Mediators of inflammation · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designThe importance of cytokine- and chemokine-mediated neuroinflammation in the progress of brain injury is becoming increasingly evident. We investigated the early local cytokine and chemokine expression and the development of tissue injury after moderate mechanical hippocampus trauma. MATERIAL OR SUBJECTS: Mouse organotypic hippocampal slice cultures. TREATMENT: Drop-weight trauma in the CA1 region of the hippocampus.
methodsStaining of necrotic tissue, PCR array and evaluation, real-time PCR, statistical analysis with a two-tailed, independent t test.
resultsAt 12 and 24 h after trauma, the tissue injury spread from the primary mechanical lesion to the entire hippocampal formation. A pronounced up-regulation of distinct chemokine transcripts was found 4 h after in vitro traumatic brain injury which preceded the development of the secondary injury.
conclusionsThe enhanced expression of inflammatory genes might contribute to the development of the secondary trauma and could pinpoint future neuroinflammatory and neuroprotective targets for research and treatment.
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