ArticleCellular and molecular life sciences : CMLS2011
Isotocin controls ion regulation through regulating ionocyte progenitor differentiation and proliferation.
Article in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 66 citations in OpenAlex.
- Serotonin stimulates proliferation of ionocytes via the 5-HT2A receptor in zebrafish larvae.The Journal of experimental biology · 2026Article
- Multi-transmitter characteristics and functional specialization of oxytocin neuron subpopulations in zebrafish.The Journal of experimental biology · 2026Article
- Hypo-Osmoregulatory Roles of Vasotocinergic and Isotocinergic Systems in the Intestines of Two European Sea Bass Lineages.International journal of molecular sciences · 2022Article
- Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes.Frontiers in endocrinology · 2022Review
- Article
- Revelation of candidate genes and molecular mechanism of reproductive seasonality in female rohu (Labeo rohita Ham.) by RNA sequencing.BMC genomics · 2021Article
- Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish.International journal of molecular sciences · 2021Article
- Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes.Developmental cell · 2021Article
- Calcium State-Dependent Regulation of Epithelial Cell Quiescence by Stanniocalcin 1a.Frontiers in cell and developmental biology · 2021Article
- Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and HInternational journal of molecular sciences · 2020Article
- Article
- The Control of Calcium Metabolism in Zebrafish (Danio rerio).International journal of molecular sciences · 2016Review
- A novel function of calcitonin gene-related peptide in body fluid Cl- homeostasis.Proceedings. Biological sciences · 2016Article
- Hydrogen sulfide inhibits Na+ uptake in larval zebrafish, Danio rerio.Pflugers Archiv : European journal of physiology · 2015Article
- Stanniocalcin-1 controls ion regulation functions of ion-transporting epithelium other than calcium balance.International journal of biological sciences · 2015Article
- Cortisol Regulates Acid Secretion of H(+)-ATPase-rich Ionocytes in Zebrafish (Danio rerio) Embryos.Frontiers in physiology · 2015Article
- Osmoregulation in zebrafish: ion transport mechanisms and functional regulation.EXCLI journal · 2015Review
- Prolactin and teleost ionocytes: new insights into cellular and molecular targets of prolactin in vertebrate epithelia.General and comparative endocrinology · 2014Review
- The role of cAMP-mediated intracellular signaling in regulating Na+ uptake in zebrafish larvae.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Zebrafish as an animal model to study ion homeostasis.Pflugers Archiv : European journal of physiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study using zebrafish as a model explores the role of isotocin, a homolog of oxytocin, in controlling ion regulatory mechanisms. Double-deionized water treatment for 24 h significantly stimulated isotocin mRNA expression in zebrafish embryos. Whole-body Cl(-), Ca(2+), and Na(+) contents, mRNA expressions of ion transporters and ionocyte-differentiation related transcription factors, and the number of skin ionocytes decreased in isotocin morphants. In contrast, overexpression of isotocin caused an increase in ionocyte numbers. Isotocin morpholino caused significant suppression of foxi3a mRNA expression, while isotocin cRNA stimulated foxi3a mRNA expressions at the tail-bud stage of zebrafish embryos. The density of P63 (an epidermal stem cell marker)-positive cells was downregulated by isotocin morpholinos and was upregulated by isotocin cRNA. Taken together, isotocin stimulates the proliferation of epidermal stem cells and differentiation of ionocyte progenitors by regulating the P63 and Foxi3a transcription factors, consequently enhancing the functional activities of ionocytes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.