ReviewHuman genetics2011
Regions of homozygosity and their impact on complex diseases and traits.
Review in Human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed.
- Runs of homozygosity in Italian Holstein bulls: a permutation approach and time-based mapping of the genomic regions potentially under selection.BMC genomics · 2026Article
- The Influence of Demographic History and Genetic Architecture on Complex Traits via Runs of Homozygosity.bioRxiv : the preprint server for biology · 2025Article
- Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank.Journal of human genetics · 2025Article
- Measures of Homozygosity and Relationship to Genetic Diversity in the Bearded Collie Breed.Genes · 2025Article
- Prenatal diagnosis and genetic analysis of small supernumerary marker chromosomes in the eastern chinese han population: A retrospective study of 36 cases.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2024Article
- Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink.BMC genomic data · 2024Article
- Article
- Genome-wide scan for runs of homozygosity in South American Camelids.BMC genomics · 2023Article
- Genomic selection analysis of morphological and adaptation traits in Chinese indigenous dog breeds.Frontiers in veterinary science · 2023Article
- Article
- Simultaneous testing of rule- and model-based approaches for runs of homozygosity detection opens up a window into genomic footprints of selection in pigs.BMC genomics · 2022Article
- Genome-wide detection of genetic structure and runs of homozygosity analysis in Anhui indigenous and Western commercial pig breeds using PorcineSNP80k data.BMC genomics · 2022Article
- Clinical experience of noninvasive prenatal testing for rare chromosome abnormalities in singleton pregnancies.Frontiers in genetics · 2022Article
- Challenges in quantifying genome erosion for conservation.Frontiers in genetics · 2022Review
- The Concept of Immunogenetics.Advances in experimental medicine and biology · 2022Article
- Exploring genetic diversity and population structure of Punjab goat breeds using Illumina 50 K SNP bead chip.Tropical animal health and production · 2021Article
- Genetic Diversity and Signatures of Selection for Thermal Stress in Cattle and Other TwoFrontiers in genetics · 2021Article
- Runs of homozygosity and analysis of inbreeding depression.Journal of animal science · 2020Article
- Genome-Wide Assessment of Runs of Homozygosity in Chinese Wagyu Beef Cattle.Animals : an open access journal from MDPI · 2020Article
- Genomic Signatures After Five Generations of Intensive Selective Breeding: Runs of Homozygosity and Genetic Diversity in Representative Domestic and Wild Populations of Turbot (Frontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regions of homozygosity (ROHs) are more abundant in the human genome than previously thought. These regions are without heterozygosity, i.e. all the genetic variations within the regions have two identical alleles. At present there are no standardized criteria for defining the ROHs resulting in the different studies using their own criteria in the analysis of homozygosity. Compared to the era of genotyping microsatellite markers, the advent of high-density single nucleotide polymorphism genotyping arrays has provided an unparalleled opportunity to comprehensively detect these regions in the whole genome in different populations. Several studies have identified ROHs which were associated with complex phenotypes such as schizophrenia, late-onset of Alzheimer's disease and height. Collectively, these studies have conclusively shown the abundance of ROHs larger than 1 Mb in outbred populations. The homozygosity association approach holds great promise in identifying genetic susceptibility loci harboring recessive variants for complex diseases and traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.