ArticleRadiation and environmental biophysics2011
Low-dose irradiation causes rapid alterations to the proteome of the human endothelial cell line EA.hy926.
Article in Radiation and environmental biophysics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- A Review of Radiation-Induced Alterations of Multi-Omic Profiles, Radiation Injury Biomarkers, and Countermeasures.Radiation research · 2023Review
- Clinical Trial in a Dish for Space Radiation Countermeasure Discovery.Life sciences in space research · 2022Review
- Mechanisms of radiation-induced endothelium damage: Emerging models and technologies.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021Review
- Biomarkers of radiation-induced vascular injury.Cancer reports (Hoboken, N.J.) · 2019Review
- Pathological effects of ionizing radiation: endothelial activation and dysfunction.Cellular and molecular life sciences : CMLS · 2019Review
- Effect of Ionizing Radiation on Human EA.hy926 Endothelial Cells under Inflammatory Conditions and Their Interactions with A549 Tumour Cells.Journal of immunology research · 2019Article
- Proteomic Changes in Mouse Spleen after Radiation-Induced Injury and its Modulation by Gamma-Tocotrienol.Radiation research · 2018Article
- Fibronectin Produced by Cerebral Endothelial and Vascular Smooth Muscle Cells Contributes to Perivascular Extracellular Matrix in Late-Delayed Radiation-Induced Brain Injury.Radiation research · 2018Article
- Cardiovascular diseases related to ionizing radiation: The risk of low-dose exposure (Review).International journal of molecular medicine · 2016Review
- Brain Radiation Information Data Exchange (BRIDE): integration of experimental data from low-dose ionising radiation research for pathway discovery.BMC bioinformatics · 2016Article
- Ionizing radiation induces immediate protein acetylation changes in human cardiac microvascular endothelial cells.Journal of radiation research · 2015Article
- Quantitative Proteomic Profiling of Low-Dose Ionizing Radiation Effects in a Human Skin Model.Proteomes · 2014Article
- Proteomics in radiation research: present status and future perspectives.Radiation and environmental biophysics · 2014Review
- High and low doses of ionizing radiation induce different secretome profiles in a human skin model.PloS one · 2014Article
- Integrative proteomic and microRNA analysis of primary human coronary artery endothelial cells exposed to low-dose gamma radiation.Radiation and environmental biophysics · 2013Article
- Cell survival following radiation exposure requires miR-525-3p mediated suppression of ARRB1 and TXN1.PloS one · 2013Article
- The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation.PloS one · 2013Article
- Immunomodulatory properties and molecular effects in inflammatory diseases of low-dose x-irradiation.Frontiers in oncology · 2012Article
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High doses of ionising radiation damage the heart by an as yet unknown mechanism. A concern for radiological protection is the recent epidemiological data indicating that doses as low as 100-500 mGy may induce cardiac damage. The aim of this study was to identify potential molecular targets and/or mechanisms involved in the pathogenesis of low-dose radiation-induced cardiovascular disease. The vascular endothelium plays a pivotal role in the regulation of cardiac function and is therefore a potential target tissue. We report here that low-dose radiation induced rapid and time-dependent changes in the cytoplasmic proteome of the human endothelial cell line EA.hy926. The proteomes were investigated at 4 and 24 h after irradiation at two different dose rates (Co-60 gamma ray total dose 200 mGy; 20 mGy/min and 190 mGy/min) using 2D-DIGE technology. Differentially expressed proteins were identified, after in-gel trypsin digestion, by MALDI-TOF/TOF tandem mass spectrometry, and peptide mass fingerprint analyses. We identified 15 significantly differentially expressed proteins, of which 10 were up-regulated and 5 down-regulated, with more than ±1.5-fold difference compared with unexposed cells. Pathways influenced by the low-dose exposures included the Ran and RhoA pathways, fatty acid metabolism and stress response.
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