Evidence map›Paper›PMID 21104259›Full record

ReviewHerzschrittmachertherapie & Elektrophysiologie2010

[Dronedarone].

B-D Gonska

Abstract readComparative StudyReview
PubMed Publisher
In one paragraph

Review in Herzschrittmachertherapie & Elektrophysiologie, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

B-D GonskaSt. Vincentius-Kliniken Karlsruhe, Med. Klinik III - Kardiologie, Angiologie, Intensivmedizin, Akademisches Lehrkrankenhaus der Universität Freiburg, Südendstrasse 32, 76137, Karlsruhe, Deutschland. prof.gonska@vincentius-ka.de

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dronedarone is a new antiarrhythmic agent, approved in January 2010 for the therapy of atrial fibrillation and for rate control in tachyarrhythmic atrial fibrillation. It was developed with the goal of replicating the high antiarrhythmic potency of amiodarone but with fewer side effects. An essential difference compared to amiodarone is the elimination of the iodine substituents in order to avoid the thyroid side effects and the addition of a methane-sulfonamyl group group in order to reduce lipophilicity. In the meantime, the Guidelines of the European Society of Cardiology list dronedarone in the group of antiarrhythmically effective substances along with the class 1c antiarrhythmia agents and amiodarone that can be administered before catheter ablation. Dronedarone is a well-tolerated antiarrhythmic agent, which due to its side effect profile permits its application in an outpatient setting in patients with atrial fibrillation.

Indexed as

AmiodaroneAnti-Arrhythmia AgentsAtrial FibrillationBiological AvailabilityCatheter AblationCombined Modality TherapyDose-Response Relationship, DrugDronedaroneElectrocardiographyHumansPractice Guidelines as TopicPremedicationRandomized Controlled Trials as TopicAmiodaroneAnti-Arrhythmia AgentsDronedarone

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.