Evidence map›Paper›PMID 21104160›Full record

ReviewFrontiers of medicine in China2010

Molecular mechanisms of leukemia-associated protein degradation.

Ying-Li Wu, Hu-Chen Zhou, Guo-Qiang Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Frontiers of medicine in China, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Effector caspases and leukemia.International journal of cell biology · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ying-Li WuDepartment of Pathophysiology and Chemical Biology Division of Shanghai Universities E-Institutes, Key laboratory of Cell Differentiation and Apoptosis of the Ministry of Education of China, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, China.
Hu-Chen Zhou
Guo-Qiang Chen
Shanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical biology, using small molecules as probes to study the cellular signaling network, has developed rapidly in recent years. The interaction between chemistry and biology not only provides new insight into the understanding of cellular activities, but also generates new lead compounds for the treatment of diseases. Transcription factors and kinases such as retinoic acid receptor-alpha (RARα), acute myeloid leukemia 1 (AML1), CAAT/enhancer-binding protein α (C/EBPα), c-myc, and c-abl play important roles in the differentiation of hematopoietic stem/progenitor cells. Abnormalities in these proteins may cause the dysregulation of hematopoiesis and even the occurrence of leukemia. Ubiquitin-mediated protein degradation represents a critical mechanism in regulating the cellular levels and functions of these proteins. Thus, targeting protein degradation has been emerging as an important strategy to conquer malignant diseases. In this review, we will summarize the recent advances in the understanding of the roles of protein degradation in leukemia, with an emphasis on the mechanisms revealed by small molecules.

Indexed as

CCAAT-Enhancer-Binding Protein-alphaCore Binding Factor Alpha 2 SubunitFusion Proteins, bcr-ablGene Expression Regulation, LeukemicHumansLeukemia, MyeloidOncogene Proteins, FusionProtein KinasesProto-Oncogene Proteins c-mycReceptors, Retinoic AcidRetinoic Acid Receptor alphaRUNX1 Translocation Partner 1 ProteinTranscription FactorsUbiquitinAML1-ETO fusion protein, humanCCAAT-Enhancer-Binding Protein-alphaCore Binding Factor Alpha 2 SubunitFusion Proteins, bcr-ablMYC protein, humanOncogene Proteins, Fusionpromyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinProtein KinasesProto-Oncogene Proteins c-mycRARA protein, humanReceptors, Retinoic AcidRetinoic Acid Receptor alphaRUNX1 protein, humanRUNX1 Translocation Partner 1 ProteinTranscription FactorsUbiquitin

Identifiers

PMID21104160
OpenAlexW2054545358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.