ArticleHuman genetics2011
Genetic risk sum score comprised of common polygenic variation is associated with body mass index.
Article in Human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.European journal of human genetics : EJHG · 2012Pooled it
- Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study.Nutrients · 2017Trial
- Influence of treatment, genetic predisposition, and lifestyle on cardiovascular risk factors among cancer survivors.Journal of the National Cancer Institute · 2026Article
- Interaction between genetic susceptibility to obesity and food intake on BMI in Finnish school-aged children.Scientific reports · 2023Article
- Assessing the prediction of type 2 diabetes risk using polygenic and clinical risk scores in South Asian study populations.Therapeutic advances in endocrinology and metabolism · 2023Article
- Interactive effects of the low-carbohydrate diet score and genetic risk score on Hypo-HDL-cholesterolemia among Korean adults: A cross-sectional analysis from the Ansan and Ansung Study of the Korean Genome and Epidemiology Study.Food science & nutrition · 2022Article
- Polygenic risk scores: An overview from bench to bedside for personalised medicine.Frontiers in genetics · 2022Review
- Effect of dietary fat intake and genetic risk on glucose and insulin-related traits in Brazilian young adults.Journal of diabetes and metabolic disorders · 2021Article
- Genetic underpinnings of regional adiposity distribution in African Americans: Assessments from the Jackson Heart Study.PloS one · 2021Article
- The Disruptive Effects of Estrogen Removal before Puberty on Risk for Binge Eating in Female Rats.Clinical psychological science : a journal of the Association for Psychological Science · 2020Article
- Interaction between Metabolic Genetic Risk Score and Dietary Fatty Acid Intake on Central Obesity in a Ghanaian Population.Nutrients · 2020Article
- The Challenge of Stratifying Obesity: Attempts in the Quebec Family Study.Frontiers in genetics · 2019Article
- Health risk prediction models incorporating personality data: Motivation, challenges, and illustration.Personality disorders · 2019Article
- CRISPR/Cas9, the Powerful New Genome-Editing Tool for Putative Therapeutics in Obesity.Journal of molecular neuroscience : MN · 2018Review
- Development of multivariable models to predict change in Body Mass Index within a clinical trial population of psychotic individuals.Scientific reports · 2017Article
- Relationships between GAT1 and PTSD, Depression, and Substance Use Disorder.Brain sciences · 2017Article
- A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores.Methods in molecular biology (Clifton, N.J.) · 2017Article
- A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Assessment of first and second degree relatives of individuals with bipolar disorder shows increased genetic risk scores in both affected relatives and young At-Risk Individuals.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Article
- A genetic risk score combining 32 SNPs is associated with body mass index and improves obesity prediction in people with major depressive disorder.BMC medicine · 2015Article
Corrections and comments
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9 authors.
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Abstract
Genome-wide association studies (GWAS) of body mass index (BMI) using large samples have yielded approximately a dozen robustly associated variants and implicated additional loci. Individually these variants have small effects and in aggregate explain a small proportion of the variance. As a result, replication attempts have limited power to achieve genome-wide significance, even with several thousand subjects. Since there is strong prior evidence for genetic influence on BMI for specific variants, alternative approaches to replication can be applied. Instead of testing individual loci sequentially, a genetic risk sum score (GRSS) summarizing the total number of risk alleles can be tested. In the current study, GRSS comprising 56 top variants catalogued from two large meta-analyses was tested for association with BMI in the Molecular Genetics of Schizophrenia controls (2,653 European-Americans, 973 African-Americans). After accounting for covariates known to influence BMI (ancestry, sex, age), GRSS was highly associated with BMI (p value = 3.19 E-06) although explained a limited amount of the variance (0.66%). However, area under receiver operator criteria curve (AUC) estimates indicated that the GRSS and covariates significantly predicted overweight and obesity classification with maximum discriminative ability for predicting class III obesity (AUC = 0.697). The relative contributions of the individual loci to GRSS were examined post hoc and the results were not due to a few highly significant variants, but rather the result of numerous variants of small effect. This study provides evidence of the utility of a GRSS as an alternative approach to replication of common polygenic variation in complex traits.
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