ReviewHeart failure reviews2011
Mechano-energetics of the asynchronous and resynchronized heart.
Review in Heart failure reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Left Bundle Branch Area Pacing in Heart Failure: A Physiological Alternative to Conventional Biventricular Cardiac Resynchronization Therapy and a Step Towards Personalized Device Therapy.Journal of personalized medicine · 2026Review
- Conduction System Pacing Improved Cardiac Functions, Myocardial Work and Functional Capacity in Heart Failure with Reduced Ejection Fraction and Right Bundle Branch Block.Journal of clinical medicine · 2025Article
- Considering Diastolic Dyssynchrony as a Predictor of Favorable Response in LV-Only Fusion Pacing Cardiac Resynchronization Therapy.Diagnostics (Basel, Switzerland) · 2023Article
- Mechanical Dyssynchrony of Isolated Left and Right Ventricular Human Myocardium in End-Stage Heart Failure.Circulation. Heart failure · 2023Article
- An Electrocardiographic Characterization of Left Bundle Branch Area Pacing-Induced Right Ventricular Activation Delay: A Comparison With Native Right Bundle Branch Block.Frontiers in cardiovascular medicine · 2022Article
- Acute recoordination rather than functional hemodynamic improvement determines reverse remodelling by cardiac resynchronisation therapy.The international journal of cardiovascular imaging · 2021Article
- Segment length in cine (SLICE) strain analysis: a practical approach to estimate potential benefit from cardiac resynchronization therapy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- An Analysis of Myocardial Efficiency in Patients with Severe Asymptomatic Mitral Regurgitation.Journal of cardiovascular imaging · 2020Article
- Efficiency is key.European heart journal. Cardiovascular Imaging · 2020Article
- Strain imaging to predict response to cardiac resynchronization therapy: a systematic comparison of strain parameters using multiple imaging techniques.ESC heart failure · 2018Article
- Cardiac Resynchronization Therapy in Pediatrics.The Journal of innovations in cardiac rhythm management · 2018Review
- Resynchronization Therapy for Patients with Congenital Heart Disease: Are We Ready for Prime Time?Current cardiology reports · 2018Review
- Strain analysis in CRT candidates using the novel segment length in cine (SLICE) post-processing technique on standard CMR cine images.European radiology · 2017Article
- Pilot study using 3D-longitudinal strain computation in a multi-parametric approach for best selecting responders to cardiac resynchronization therapy.Cardiovascular ultrasound · 2017Article
- Clinical Long-Term Response to Cardiac Resynchronization Therapy Is Independent of Persisting Echocardiographic Markers of Dyssynchrony.Cardiology research · 2014Article
- Strategies to improve cardiac resynchronization therapy.Nature reviews. Cardiology · 2014Review
- Myocardial oxidative metabolism, blood flow and efficiency in rapid pacing induced heart failure in dogs.International journal of physiology, pathophysiology and pharmacology · 2014Article
- Article
- Modeling cardiac electromechanics and mechanoelectrical coupling in dyssynchronous and failing hearts: insight from adaptive computer models.Journal of cardiovascular translational research · 2012Review
Corrections and comments
- Erratum issuedDeboeck, Bart W L [corrected to De Boeck, Bart W L]
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal electrical activation of the ventricles creates major abnormalities in cardiac mechanics. Local contraction patterns, as reflected by measurements of local strain, are not only out of phase, but often also show opposing length changes in early and late activated regions. As a consequence, the efficiency of cardiac pump function (the amount of stroke work generated by a unit of oxygen consumed) is approximately 30% lower in asynchronous than in synchronous hearts. Moreover, the amount of work performed in myocardial segments becomes considerably larger in late than in early activated regions. Cardiac Resynchronization Therapy (CRT) improves mechano-energetics of the previously asynchronous heart in various ways: it alleviates impediment of the abnormal contraction on blood flow, it increases myocardial efficiency, it recruits contraction in the previously early activated septum and it creates a more uniform distribution of myocardial blood flow. These factors act together to increase the range of cardiac work that can be delivered by the patients' heart, an effect that can explain the increased exercise tolerance and quality of life reported in several CRT trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.