ArticlePloS one2010
Intraspecies prion transmission results in selection of sheep scrapie strains.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Evidence for multiple prion conformers in natural scrapie isolates.PLoS pathogens · 2026Article
- Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation.Acta neuropathologica communications · 2023Article
- Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains.Scientific reports · 2020Article
- Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate.Veterinary research · 2018Article
- Evolutionary biology and the risk of scrapie disease in sheep.Open veterinary journal · 2018Review
- Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells.PloS one · 2017Article
- Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE.Scientific reports · 2016Article
- Ability of wild type mouse bioassay to detect bovine spongiform encephalopathy (BSE) in the presence of excess scrapie.Acta neuropathologica communications · 2015Article
- Phenotype shift from atypical scrapie to CH1641 following experimental transmission in sheep.PloS one · 2015Article
- Article
- Sheep prions with molecular properties intermediate between classical scrapie, BSE and CH1641-scrapie.Prion · 2014Article
- Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain.Pathogens (Basel, Switzerland) · 2013Article
- The N-terminal sequence of prion protein consists an epitope specific to the abnormal isoform of prion protein (PrP(Sc)).PloS one · 2013Article
- Use of murine bioassay to resolve ovine transmissible spongiform encephalopathy cases showing a bovine spongiform encephalopathy molecular profile.Brain pathology (Zurich, Switzerland) · 2012Article
- An overview of animal prion diseases.Virology journal · 2011Review
- Distinct proteinase K-resistant prion protein fragment in goats with no signs of disease in a classical scrapie outbreak.Journal of clinical microbiology · 2011Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSheep scrapie is caused by multiple prion strains, which have been classified on the basis of their biological characteristics in inbred mice. The heterogeneity of natural scrapie prions in individual sheep and in sheep flocks has not been clearly defined. METHODOLOGY/PRINCIPAL
findingsIn this study, we intravenously injected 2 sheep (Suffolk and Corriedale) with material from a natural case of sheep scrapie (Suffolk breed). These 3 sheep had identical prion protein (PrP) genotypes. The protease-resistant core of PrP (PrPres) in the experimental Suffolk sheep was similar to that in the original Suffolk sheep. In contrast, PrPres in the Corriedale sheep differed from the original PrPres but resembled the unusual scrapie isolate, CH1641. This unusual PrPres was not detected in the original sheep. The PrPres distributions in the brain and peripheral tissues differed between the 2 breeds of challenged sheep. A transmission study in wild-type and TgBoPrP mice, which overexpressing bovine PrP, led to the selection of different prion strains. The pathological features of prion diseases are thought to depend on the dominantly propagated strain. CONCLUSIONS/SIGNIFICANCE: Our results indicate that prion strain selection occurs after both inter- and intraspecies transmission. The unusual scrapie prion was a hidden or an unexpressed component in typical sheep scrapie.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.