ArticleFrontiers in human neuroscience2010
Are Bipolar Disorder and Schizophrenia Neuroanatomically Distinct? An Anatomical Likelihood Meta-analysis.
Article in Frontiers in human neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 6 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Gray Matter Abnormalities in Type 1 and Type 2 Diabetes: A Dual Disorder ALE Quantification.Frontiers in neuroscience · 2021Pooled it
- At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk.Schizophrenia bulletin · 2013Pooled it
- Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis.Journal of psychiatry & neuroscience : JPN · 2012Pooled it
- Structural brain changes in First Episode Schizophrenia compared with Fronto-Temporal Lobar Degeneration: a meta-analysis.BMC psychiatry · 2012Pooled it
- Meta-analytic evidence for a superordinate cognitive control network subserving diverse executive functions.Cognitive, affective & behavioral neuroscience · 2012Pooled it
- Can Asperger syndrome be distinguished from autism? An anatomic likelihood meta-analysis of MRI studies.Journal of psychiatry & neuroscience : JPN · 2011Pooled it
- Reassessing Asymmetry Reduction in Psychosis: Cingulate Folding and Gyrification Covariance in Patients with Auditory Hallucinations.Schizophrenia bulletin · 2026Article
- Neuronal Synaptic Communication and Mitochondrial Energetics in Human Health and Disease.Advances in experimental medicine and biology · 2025Review
- Neurostructural changes in schizophrenia and treatment-resistance: a narrative review.Psychoradiology · 2024Review
- Supervised machine learning classification of psychosis biotypes based on brain structure: findings from the Bipolar-Schizophrenia network for intermediate phenotypes (B-SNIP).Scientific reports · 2023Article
- Gut microbial signatures and differences in bipolar disorder and schizophrenia of emerging adulthood.CNS neuroscience & therapeutics · 2023Article
- Perceiving visual negative stimuli in schizophrenia and bipolar disorder: Meta-analytic evidence of a common altered thalamic-parahippocampal-basal ganglia circuit.Neuroimage. Reports · 2023Article
- Segregation, integration and balance in resting-state brain functional networks associated with bipolar disorder symptoms.Human brain mapping · 2023Article
- Diagnosis- and Cell Type-Specific Mitochondrial Functional Pathway Signatures in Schizophrenia and Bipolar Disorder.The American journal of psychiatry · 2020Article
- Article
- Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Mitochondria under the spotlight: On the implications of mitochondrial dysfunction and its connectivity to neuropsychiatric disorders.Computational and structural biotechnology journal · 2020Review
- Article
- Self-Awareness of Psychopathology and Brain Volume in Patients With First Episode Psychosis.Frontiers in psychiatry · 2019Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere is renewed debate on whether modern diagnostic classification should adopt a dichotomous or dimensional approach to schizophrenia and bipolar disorder. This study synthesizes data from voxel-based studies of schizophrenia and bipolar disorder to estimate the extent to which these conditions have a common neuroanatomical phenotype.
methodsA post-hoc meta-analytic estimation of the extent to which bipolar disorder, schizophrenia, or both conditions contribute to brain gray matter differences compared to controls was achieved using a novel application of the conventional anatomical likelihood estimation (ALE) method. 19 schizophrenia studies (651 patients and 693 controls) were matched as closely as possible to 19 bipolar studies (540 patients and 745 controls).
resultSubstantial overlaps in the regions affected by schizophrenia and bipolar disorder included regions in prefrontal cortex, thalamus, left caudate, left medial temporal lobe, and right insula. Bipolar disorder and schizophrenia jointly contributed to clusters in the right hemisphere, but schizophrenia was almost exclusively associated with additional gray matter deficits (left insula and amygdala) in the left hemisphere. LIMITATION: The current meta-analytic method has a number of constraints. Importantly, only studies identifying differences between controls and patient groups could be included in this analysis.
conclusionBipolar disorder shares many of the same brain regions as schizophrenia. However, relative to neurotypical controls, lower gray matter volume in schizophrenia is more extensive and includes the amygdala. This fresh application of ALE accommodates multiple studies in a relatively unbiased comparison. Common biological mechanisms may explain the neuroanatomical overlap between these major disorders, but explaining why brain differences are more extensive in schizophrenia remains challenging.
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