ArticleNature reviews. Genetics2011
Statistical interaction in human genetics: how should we model it if we are looking for biological interaction?
Article in Nature reviews. Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ultrafast genome-wide scan for SNP-SNP interactions in common complex disease.Genome research · 2012Pooled it
- Performance of deep-learning-based approaches to improve polygenic scores.Nature communications · 2025Article
- Article
- Translational genomics and beyond in bipolar disorder.Molecular psychiatry · 2021Review
- VARIABLE PRIORITIZATION IN NONLINEAR BLACK BOX METHODS: A GENETIC ASSOCIATION CASE STUDYThe annals of applied statistics · 2019Article
- Asymmetric independence modeling identifies novel gene-environment interactions.Scientific reports · 2019Article
- Statistical interactions and Bayes estimation of log odds in case-control studies.Statistical methods in medical research · 2017Article
- Efficient Strategy to Identify Gene-Gene Interactions and Its Application to Type 2 Diabetes.Genomics & informatics · 2016Article
- Quantifying Treatment Benefit in Molecular Subgroups to Assess a Predictive Biomarker.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Review
- Statistical Interactions from a Growth Curve Perspective.Human heredity · 2016Article
- Analysis pipeline for the epistasis search - statistical versus biological filtering.Frontiers in genetics · 2014Review
- A robustness study of parametric and non-parametric tests in model-based multifactor dimensionality reduction for epistasis detection.BioData mining · 2013Article
- Evaluation of removable statistical interaction for binary traits.Statistics in medicine · 2013Article
- eQTL Epistasis - Challenges and Computational Approaches.Frontiers in genetics · 2013Article
- Power of single- vs. multi-marker tests of association.Genetic epidemiology · 2012Article
- Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.Neurology · 2012Article
- Symmetric Epistasis Estimation (SEE) and its application to dissecting interaction map of Plasmodium falciparum.Molecular bioSystems · 2012Article
- Genetic terminology.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Article
- Testing gene-environment interactions in gene-based association studies.BMC proceedings · 2011Article
Corrections and comments
- Comment on
Authors and funding
3 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.