ReviewAsian journal of andrology2011
Diagnostic tools in male infertility-the question of sperm dysfunction.
Review in Asian journal of andrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06188936 (Home Semen Analysis Tests As a Screening Tool for the Initial Assessment of Patients Referred to the Fertility Clinic), which is not on this map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Home Semen Analysis Tests As a Screening Tool for the Initial Assessment of Patients Referred to the Fertility Clinic: Assessing the Feasibility of a Randomised Trial in the UK
Who cites it
33 citing papers in PubMed, 92 citations in OpenAlex.
- Cost-benefit potential of sperm function testing to the treatment pathway for unexplained infertility: a modelling study from the UK NHS perspective.Health economics review · 2026Article
- Spermatozoa centriole quality determined by FRAC may correlate with zygote nucleoli polarization-a pilot study.Journal of assisted reproduction and genetics · 2025Article
- Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation.The Journal of clinical investigation · 2024Article
- Effects of in vitro repaglinide supplementation on improving sperm motility parameters, viability, and DNA integrity in normozoospermic and asthenozoospermic men.JBRA assisted reproduction · 2023Article
- The effect of zinc supplementation on improving sperm parameters in infertile diabetic men.Journal of obstetrics and gynaecology of India · 2023Article
- Do studies published in two leading reproduction journals between 2011 and 2020 demonstrate that they followed WHO5 recommendations for basic semen analysis?Human reproduction (Oxford, England) · 2022Article
- Lack of trusted diagnostic tools for undetermined male infertility.Journal of assisted reproduction and genetics · 2021Review
- Skin Inflammation and Testicular Function: Dermatitis Causes Male Infertility via Skin-Derived Cytokines.Biomedicines · 2020Article
- The effect of Myo-inositol on sperm parameters and pregnancy rate in oligoasthenospermic men treated with IUI: A randomized clinical trial.International journal of reproductive biomedicine · 2019Article
- Sperm physiology varies according to ultradian and infradian rhythms.Scientific reports · 2019Article
- Article
- Sperm function tests in clinical practice.Turkish journal of urology · 2017Review
- Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem.Human reproduction (Oxford, England) · 2017Article
- Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility.Molecular & cellular proteomics : MCP · 2016Article
- Oxidation-reduction potential of semen: what is its role in the treatment of male infertility?Therapeutic advances in urology · 2016Review
- Treating Woman with Myo-Inositol Vaginal Suppositories Improves Partner's Sperm Motility and Fertility.International journal of endocrinology · 2016Article
- Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa.Human reproduction (Oxford, England) · 2015Article
- Terminal Mannose Residues in Seminal Plasma Glycoproteins of Infertile Men Compared to Fertile Donors.International journal of molecular sciences · 2015Article
- Engaging practicing gynecologists in the management of infertile men.Journal of obstetrics and gynaecology of India · 2015Review
- The analysis of sialylation, N-glycan branching, and expression of O-glycans in seminal plasma of infertile men.Disease markers · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Sperm dysfunction is the single most common cause of infertility, yet what is remarkable is that, there is no drug a man can take or add to his spermatozoa in vitro to improve fertility. One reason for the lack of progress in this area is that our understanding of the cellular and molecular workings of the mature spermatazoon is limited. However, over the last few years there has been considerable progress in our knowledge base and in addressing new methods to diagnose sperm dysfunction. We review the current state of the field and provide insights for further development. We conclude that: (i) there is little to be gained from more studies identifying/categorizing various populations of men using a basic semen assessment, where an effort is required in making sure the analysis is performed in an appropriate high quality way; (ii) technological development is likely to bring the reality of sperm function testing closer to implementation into the clinical pathways. In doing this, these assays must be robust, cheap (or more appropriately termed cost effective), easy to use and clinically useful; and (iii) clinical necessity, e.g., the need to identify the highest quality spermatozoon for injection is driving basic research forward. This is an exciting time to be an andrologist and, likely, a fruitful one.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.