SynthesisNature genetics2010
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 282 papers, 17 of them syntheses that pooled it.
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282citing papers in PubMed, 17 pooled it
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What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
282 citing papers in PubMed, 17 syntheses or guidelines pooled it.
- The J shaped association of age at menarche and cardiovascular events: systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Pooled it
- Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene.Journal of human genetics · 2023Pooled it
- Age at menarche and epithelial ovarian cancer risk: A meta-analysis and Mendelian randomization study.Cancer medicine · 2019Pooled it
- Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI.International journal of obesity (2005) · 2018Pooled it
- Pooled it
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.Nature communications · 2017Pooled it
- Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.Nature communications · 2017Pooled it
- Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.Nature genetics · 2016Pooled it
- Pooled it
- Genetic studies of body mass index yield new insights for obesity biology.Nature · 2015 · on this mapPooled it
- Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.Human molecular genetics · 2014Pooled it
- Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.Nature genetics · 2014Pooled it
- DNA mismatch repair gene MSH6 implicated in determining age at natural menopause.Human molecular genetics · 2014Pooled it
- Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits.BMC genetics · 2014Pooled it
- Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.American journal of human genetics · 2014Pooled it
- On individual genome-wide association studies and their meta-analysis.Human genetics · 2014Pooled it
- Pubertal development in healthy children is mirrored by DNA methylation patterns in peripheral blood.Scientific reports · 2016Trial
- No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer risk.Molecular biology and evolution · 2026Article
- CYP19A1 variation in healthy children: associations with breast development and pubertal gynecomastia.Endocrine connections · 2026Article
222 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
175 authors.
Cathy E ElksMedical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
John R B Perry
Patrick Sulem
Daniel I Chasman
Nora Franceschini
Chunyan He
Kathryn L Lunetta
Jenny A Visser
Enda M Byrne
Diana L Cousminer
Daniel F Gudbjartsson
Tõnu Esko
Bjarke Feenstra
Jouke-Jan Hottenga
Daniel L Koller
Zoltán Kutalik
Peng Lin
Massimo Mangino
Mara Marongiu
Patrick F McArdle
Albert V Smith
Lisette Stolk
Sophie H van Wingerden
Jing Hua Zhao
Eva Albrecht
Tanguy Corre
Erik Ingelsson
Caroline Hayward
Patrik K E Magnusson
Erin N Smith
Shelia Ulivi
Nicole M Warrington
Lina Zgaga
Helen Alavere
Najaf Amin
Thor Aspelund
Stefania Bandinelli
Inês Barroso
Gerald S Berenson
Sven Bergmann
Hannah Blackburn
Eric Boerwinkle
Julie E Buring
Fabio Busonero
Harry Campbell
Stephen J Chanock
Wei Chen
Marilyn C Cornelis
David Couper
Andrea D Coviello
Pio d'Adamo
Ulf de Faire
Eco J C de Geus
Panos Deloukas
Angela Döring
George Davey Smith
Douglas F Easton
Gudny Eiriksdottir
Valur Emilsson
Johan Eriksson
Luigi Ferrucci
Aaron R Folsom
Tatiana Foroud
Melissa Garcia
Paolo Gasparini
Frank Geller
Christian Gieger
GIANT Consortium
Vilmundur Gudnason
Per Hall
Susan E Hankinson
Liana Ferreli
Andrew C Heath
Dena G Hernandez
Albert Hofman
Frank B Hu
Thomas Illig
Marjo-Riitta Järvelin
Andrew D Johnson
David Karasik
Kay-Tee Khaw
Douglas P Kiel
Tuomas O Kilpeläinen
Ivana Kolcic
Peter Kraft
Lenore J Launer
Joop S E Laven
Shengxu Li
Jianjun Liu
Daniel Levy
Nicholas G Martin
Wendy L McArdle
Mads Melbye
Vincent Mooser
Jeffrey C Murray
Sarah S Murray
Michael A Nalls
Pau Navarro
Mari Nelis
Andrew R Ness
Kate Northstone
Ben A Oostra
Munro Peacock
Lyle J Palmer
Aarno Palotie
Guillaume Paré
Alex N Parker
Nancy L Pedersen
Leena Peltonen
Craig E Pennell
Paul Pharoah
Ozren Polasek
Andrew S Plump
Anneli Pouta
Eleonora Porcu
Thorunn Rafnar
John P Rice
Susan M Ring
Fernando Rivadeneira
Igor Rudan
Cinzia Sala
Veikko Salomaa
Serena Sanna
David Schlessinger
Nicholas J Schork
Angelo Scuteri
Ayellet V Segrè
Alan R Shuldiner
Nicole Soranzo
Ulla Sovio
Sathanur R Srinivasan
David P Strachan
Mar-Liis Tammesoo
Emmi Tikkanen
Daniela Toniolo
Kim Tsui
Laufey Tryggvadottir
Jonathon Tyrer
Manuela Uda
Rob M van Dam
Joyce B J van Meurs
Peter Vollenweider
Gerard Waeber
Nicholas J Wareham
Dawn M Waterworth
Michael N Weedon
H Erich Wichmann
Gonneke Willemsen
James F Wilson
Alan F Wright
Lauren Young
Guangju Zhai
Wei Vivian Zhuang
Laura J Bierut
Dorret I Boomsma
Heather A Boyd
Laura Crisponi
Ellen W Demerath
Cornelia M van Duijn
Michael J Econs
Tamara B Harris
David J Hunter
Ruth J F Loos
Andres Metspalu
Grant W Montgomery
Paul M Ridker
Tim D Spector
Elizabeth A Streeten
Kari Stefansson
Unnur Thorsteinsdottir
André G Uitterlinden
Elisabeth Widen
Joanne M Murabito
Ken K Ong
Anna Murray
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JESSICA E SALVATORE · 1989 to 2026
$162.7MLaboratory of Translational GenomicsZIACP010201 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PROKUNINA-OLSSON, LIUDMILA · 2010 to 2025
$91.2MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MType 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8MVascular Moderators of the Impact of Alzheimer's Pathology in the Young-OldP01AG025204 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Milos D Ikonomovic · 2005 to 2026
$56.5MFramingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8MRisk Factors for Onset and Persistence of TMDU01DE017018 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIATCHENKO, LUDA, FILLINGIM, ROGER B · 2005 to 2016
$35.9MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MBuilding on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6MZOSUQUIDAR TRIHYDROCHLORIDE DURING CONVENTIONAL INDUCTION AND POST-REMISSIONM01RR000750 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI RODRIGUEZ, HENRY · 1985 to 2008
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Abstract
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
Indexed as
Genome-Wide Association StudyAdolescentAgingBody HeightBody SizeChildDNA Copy Number VariationsFemaleGenetic LociGenetic Predisposition to DiseaseHumansInheritance PatternsMenarcheObesityPolymorphism, Single NucleotideQuantitative Trait Loci
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