ArticleEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2011
Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer.
Article in European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Cumulative evidence of relationships between multiple variants in 8q24 region and cancer incidence.Medicine · 2020Pooled it
- Pooled it
- Investigating the association between rs6983267 polymorphism and susceptibility to gastrointestinal cancers in Iranian population.Molecular biology reports · 2021Article
- Association between lncRNA CASC8 polymorphisms and the risk of cancer: a meta-analysis.Cancer management and research · 2018Article
- Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Complement receptor 1 genetic variants contribute to the susceptibility to gastric cancer in chinese population.Journal of Cancer · 2015Article
- Clinical significance of POU5F1P1 rs10505477 polymorphism in Chinese gastric cancer patients receving cisplatin-based chemotherapy after surgical resection.International journal of molecular sciences · 2014Article
- Genetic variation at 8q24, family history of cancer, and upper gastrointestinal cancers in a Chinese population.Familial cancer · 2014Article
- The 8q24 gene desert: an oasis of non-coding transcriptional activity.Frontiers in genetics · 2012Article
- Polymorphisms on 8q24 are associated with lung cancer risk and survival in Han Chinese.PloS one · 2012Article
- Gastric Cancer in Gorj County - a Clinical-Statistical Study.Current health sciences journalArticle
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Authors and funding
11 authors at 8 institutions in 5 countries.
Funding
Abstract
Over recent years, genome-wide association studies have contributed to our understanding of genetic susceptibility to sporadic cancer. In this study, we assessed the association between upper gastrointestinal cancer risk and four genome-wide association studies-identified single nucleotide polymorphisms (SNPs), implicated earlier in prostate and colorectal cancer susceptibility. Genotyping for each SNP was performed in two independent Caucasian population-based case-control studies. The first study comprised 290 gastric cancer cases and 374 controls. The second study included 185 noncardia gastric cancers, 123 cardia cancers, 158 oesophageal cancers and 209 controls. Odds ratios (ORs) were computed from logistic models and adjusted for potential confounding variables. An inverse association was observed between the SNP rs1447295, located at 8q24, and gastric cancer risk in the first study population (OR=0.63; 95% confidence interval: 0.41-0.97). A positive association was observed for the same SNP and oesophageal squamous cell carcinoma in the second study population (OR=7.43; 95% confidence interval: 1.37-49.98). No significant associations were detected in either study for the three remaining SNPs (rs6983297, rs10505477 and rs719725). Our data represent novel findings on heritable susceptibility to gastric and oesophageal cancer and warrant validation in additional populations.
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