ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2011
Estrogen receptor expression in sporadic vestibular schwannomas.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 33 citations in OpenAlex.
- Vestibular Schwannomas in Pregnancy: A Case Series.Journal of neurological surgery. Part B, Skull base · 2026Article
- Angiotensin-Receptor Blockers Prevent Vestibular Schwannoma-Associated Hearing Loss.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025Article
- Sex Differences in Vestibular Schwannoma.Cancers · 2023Article
- Progression of Contralateral Hearing Loss in Patients With Sporadic Vestibular Schwannoma.Frontiers in neurology · 2020Article
- A Unified Methodological Framework for Vestibular Schwannoma Research.Journal of visualized experiments : JoVE · 2017Article
- Diagnostics and therapy of vestibular schwannomas - an interdisciplinary challenge.GMS current topics in otorhinolaryngology, head and neck surgery · 2017Review
- Large Vestibular Schwannomas Presenting during Pregnancy: Management Strategies.Journal of neurological surgery. Part B, Skull base · 2014Article
- Sex-specific difference in treatment success/failure after vestibular schwannoma treatment.Neuro-oncology advancesArticle
- Prediction of treatment failure and early identification of tumor progression after Gamma-Knife radiosurgery in vestibular schwannoma: A retrospective cohort study.Neuro-oncology advancesArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
hypothesisWe hypothesize that vestibular schwannomas (VSs) exhibit up-regulation of estrogen receptor (ER) at the protein level compared with control great auricular nerve (GAN).
backgroundIt has been reported in the literature that VS occur more commonly in women and tend to be larger and more vascular in women, and growth rate can accelerate during pregnancy. The literature contains widely divergent results on ER expression in VS, however, varying from no detectable levels to detection of ER in all samples.
methodsSixteen sporadic VS specimens were immediately snap-frozen after microsurgical excision and analyzed for phosphorylated and total levels of ERα with Western blot analysis. ERα expression levels were normalized to actin; then, relative expression to GAN was determined.
resultsAll VS specimens exhibited expression of both phosphorylated and total ERα. Total ERα expression in VS is equivalent to or slightly up-regulated compared with GAN. VS specimens exhibited more pronounced up-regulation of phosphorylated (i.e., activated) levels of ERα compared with GAN.
conclusionWe have demonstrated that ERα expression in VS is equivalent to GAN. The phosphorylated form of the receptor is up-regulated compared with GAN, however, indicating a higher level of ERα activation in sporadic VS compared with normal nerve. Further investigation into antiestrogen therapy for VS is warranted.
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