Trial reportAIDS (London, England)2011
Male circumcision and risk of HIV acquisition among MSM.
Trial report in AIDS (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00076232 (A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Acyclovir for the Reduction of HIV Acquisition Among High-Risk HSV-2 Seropositive, HIV Seronegative Individuals), which is not on this map. Cited by 25 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Acyclovir for the Reduction of HIV Acquisition Among High-Risk HSV-2 Seropositive, HIV Seronegative Individuals
Who cites it
25 citing papers in PubMed, 6 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Circumcision for HIV Prevention in Men Who Have Sex With Men: An Updated Meta-Analysis.Journal of acquired immune deficiency syndromes (1999) · 2026Pooled it
- Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data.The Lancet. Global health · 2019Pooled it
- Male circumcision for prevention of homosexual acquisition of HIV in men.The Cochrane database of systematic reviews · 2011Pooled it
- Guideline
- The highest attainable standard of evidence (HASTE) for HIV/AIDS interventions: toward a public health approach to defining evidence.Public health reports (Washington, D.C. : 1974)Pooled it
- The Effect of Distraction Techniques on Pain, Fear, and Anxiety in Children Undergoing Circumcision: A Meta-Analysis of Randomized Controlled Trials.American journal of men's healthPooled it
- Trial
- Using data from 'visible' populations to estimate the size and importance of 'hidden' populations in an epidemic: A modelling technique.Infectious Disease Modelling · 2020Article
- Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review.SAGE open medicine · 2019Review
- In men at risk of HIV infection, IgM, IgG1, IgG3, and IgA reach the human foreskin epidermis.Mucosal immunology · 2016Article
- Lower HIV Risk Among Circumcised Men Who Have Sex With Men in China: Interaction With Anal Sex Role in a Cross-Sectional Study.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- The Art of HIV Elimination: Past and Present Science.Journal of AIDS & clinical research · 2015Article
- Visualization of HIV-1 interactions with penile and foreskin epithelia: clues for female-to-male HIV transmission.PLoS pathogens · 2015Article
- Client and provider perspectives on new HIV prevention tools for MSM in the Americas.PloS one · 2015Article
- Male Circumcision and HIV Transmission; What Do We Know?The open AIDS journal · 2014Article
- Risk factors for HIV/syphilis infection and male circumcision practices and preferences among men who have sex with men in China.BioMed research international · 2014Article
- Can male circumcision have an impact on the HIV epidemic in men who have sex with men?PloS one · 2014Article
- Anal sex role segregation and versatility among men who have sex with men: EXPLORE Study.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Low frequency of male circumcision and unwillingness to be circumcised among MSM in Buenos Aires, Argentina: association with sexually transmitted infections.Journal of the International AIDS Society · 2013Article
- Translation of biomedical prevention strategies for HIV: prospects and pitfalls.Journal of acquired immune deficiency syndromes (1999) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
objectivesTo assess the association between male circumcision, insertive anal sex practices, and HIV acquisition in a cohort of MSM.
methodsData were from 1824 HSV-2-seropositive, HIV-seronegative MSM, 1362 (75%) from Peru and 462 (25%) from the US, who participated in a randomized placebo-controlled trial of HSV-2 suppression for HIV prevention (HPTN 039). Circumcision status was determined by examination at enrollment. HIV testing was done every 3 months for up to 18 months. Partner-specific sexual behavior for up to the last three partners during the previous 3 months was analyzed.
resultsThere was no significant association between male circumcision and HIV acquisition in univariate analysis [relative risk (RR) = 0.84, 95% confidence interval (CI) 0.50-1.42]. In a prespecified multivariate analysis that assumed a linear relationship between the proportion of insertive acts and effect of circumcision on HIV acquisition, the interaction between circumcision and proportion of insertive acts was not significant (P = 0.11). In an exploratory analysis that categorized behavior with recent partners by proportion of insertive acts (<60 or ≥60% insertive acts), circumcision was associated with a nonstatistically significant 69% reduction in the risk of HIV acquisition (RR = 0.31, 95% CI 0.06-1.51) among men who reported at least 60% of insertive acts with recent male partners.
conclusionCircumcision does not have a significant protective effect against HIV acquisition among MSM from Peru and US, although there may be reduced risk for men who are primarily insertive with their male partners. This association needs to be investigated across diverse cohorts of MSM.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.