ArticlePediatric research2011
A murine model for disseminated candidiasis in neonates.
Article in Pediatric research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- A New Antifungal-Loaded Sol-Gel Can PreventAntibiotics (Basel, Switzerland) · 2021Article
- Evaluation of the Induction of Cell-Mediated Immunity Against Candida albicans in a Model of Cutaneous Infection in Newborn 0-Day-Old Mice.Mycopathologia · 2019Article
- Investigation ofFrontiers in microbiology · 2017Article
- Antifungal Immunological Defenses in Newborns.Frontiers in immunology · 2017Review
- Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure.Journal of neuroinflammation · 2016Article
- Neonatal Candidiasis: New Insights into an Old Problem at a Unique Host-Pathogen Interface.Current fungal infection reports · 2015Article
- Overview of vertebrate animal models of fungal infection.Journal of immunological methods · 2014Review
- Murine models of Candida gastrointestinal colonization and dissemination.Eukaryotic cell · 2013Review
- Galectin-3 plays an important role in protection against disseminated candidiasis.Medical mycology · 2013Article
- Candida albicans adhesin Als3p is dispensable for virulence in the mouse model of disseminated candidiasis.Microbiology (Reading, England) · 2011Article
- Candida albicans Als3, a multifunctional adhesin and invasin.Eukaryotic cell · 2011Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Candida albicans is the leading fungal pathogen causing invasive disease in immunocompromised patients including the neonate. A reliable animal model for disseminated candidiasis in the neonate is needed to study the unique aspects of this host-pathogen interaction. To establish such a model, 2-d-old BALB/c mouse pups were given i.p. injections with varied inocula of C. albicans or saline control. Pups were examined every 3-8 h for death. Surviving pups were killed at 72 h. Kidney, lung, spleen, liver, and brain were homogenized and plated for colony counts and/or fixed for histological staining. The i.p. injection of C. albicans led to mortality in a dose-dependent fashion. Disseminated infection was confirmed by colony counts of homogenized kidney, lung, and brain, as well as by histological examination. Infection with a C. albicans mutant lacking the cell surface adhesin, Als3p, led to significant reduction in mortality relative to WT (p = 0.03). This model will be useful to study the unique aspects of antifungal defense in a neonatal host and will provide a means to test novel therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.