ArticleJournal of vascular research2011
A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development.
Article in Journal of vascular research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Direct specification of lymphatic endothelium from mesenchymal progenitors.Nature cardiovascular research · 2025Article
- Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds.Development (Cambridge, England) · 2024Article
- Breaking a Vicious Circle: Lymphangiogenesis as a New Therapeutic Target in Wound Healing.Biomedicines · 2023Review
- Prolymphangiogenic Effects of 9-Lymphatic research and biology · 2022Article
- Engineering the Lymphatic Network: A Solution to Lymphedema.Advanced healthcare materials · 2021Review
- Retinoic acid signaling in vascular development.Genesis (New York, N.Y. : 2000) · 2019Review
- Small Peptide Modulation of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis.Lymphatic research and biology · 2019Article
- Organ-specific lymphatic vasculature: From development to pathophysiology.The Journal of experimental medicine · 2018Review
- Induction of cellular and molecular immunomodulatory pathways by vitamin A and flavonoids.Expert opinion on biological therapy · 2015Review
- Moderate vitamin A supplementation in obese mice regulates tissue factor and cytokine production in a sex-specific manner.Archives of biochemistry and biophysics · 2013Article
- Activation of the epidermal growth factor receptor promotes lymphangiogenesis in the skin.Journal of dermatological science · 2013Article
- A transgenic Xenopus laevis reporter model to study lymphangiogenesis.Biology open · 2013Article
- Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells.Stem cells (Dayton, Ohio) · 2013Article
- Review
- Possible genetic predisposition to lymphedema after breast cancer.Lymphatic research and biology · 2012Article
- Article
- Hypoxia and extracellular matrix proteins influence angiogenesis and lymphangiogenesis in mouse embryoid bodies.Frontiers in physiology · 2011Article
- Retinoic acid signaling in mouse retina endothelial cells is required for early angiogenic growth.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
The molecular mechanisms that regulate the earliest steps of lymphatic vascular system development are unknown. To identify regulators of lymphatic competence and commitment, we used an in vitro vascular assay with mouse embryonic stem cell-derived embryoid bodies (EBs). We found that incubation with retinoic acid (RA) and, more potently, with RA in combination with cAMP, induced the expression of the lymphatic competence marker LYVE-1 in the vascular structures of the EBs. This effect was dependent on RA receptor (RAR)-α and protein kinase A signaling. RA-cAMP incubation also promoted the development of CD31+/LYVE-1+/Prox1+ cell clusters. In situ studies revealed that RAR-α is expressed by endothelial cells of the cardinal vein in ED 9.5-11.5 mouse embryos. Timed exposure of mouse and Xenopus embryos to excess of RA upregulated LYVE-1 and VEGFR-3 on embryonic veins and increased formation of Prox1-positive lymphatic progenitors. These findings indicate that RA signaling mediates the earliest steps of lymphatic vasculature development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.