ArticleThe Plant cell2010
The MAP kinase MPK4 is required for cytokinesis in Arabidopsis thaliana.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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87 citing papers in PubMed, 177 citations in OpenAlex.
- A Rab/Kinesin-12/kinase module couples vesicle delivery and phragmoplast dynamics during plant cell cytokinesis.The EMBO journal · 2026Article
- Stress-induced MAPK (SIMK)-dependent organization of microtubules in alfalfa.Molecular horticulture · 2026Article
- Genome-wide identification of the MAPK gene family in peanut (Arachis hypogaea L.) and functional characterization of AhMPK3 and AhMPK18 in plant innate immunity.BMC plant biology · 2026Article
- A MAPK cascade regulates nuclear migration during female gametogenesis to establish specific cell identity and rice female fertility.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cellular dynamics and molecular signaling networks of plant cytokinesis.Molecules and cells · 2026Review
- Genome-wide identification and expression analysis reveals the drought-response MAPK genes in peanut (Arachis hypogaea L.).The plant genome · 2025Article
- Stomatal CO2 sensing in plants: control of gas exchange and interactions with environmental stimuli.Plant & cell physiology · 2025Review
- Genome-Wide Identification of MKK Gene Family and Response to Hormone and Abiotic Stress in Rice.Plants (Basel, Switzerland) · 2024Article
- Post-Translational Modifications to Cysteine Residues in Plant Proteins and Their Impact on the Regulation of Metabolism and Signal Transduction.International journal of molecular sciences · 2024Review
- Arabidopsis α-Aurora kinase plays a role in cytokinesis through regulating MAP65-3 association with microtubules at phragmoplast midzone.Nature communications · 2024Article
- MAPK Cascades in Plant Microbiota Structure and Functioning.Journal of microbiology (Seoul, Korea) · 2024Review
- Article
- Comparative transcriptome provides insights into gene regulation network associated with the resistance toFrontiers in plant science · 2023Article
- Simultaneous mutations inPlant signaling & behavior · 2022Article
- Cellular messengers involved in the inhibition of the Arabidopsis primary root growth by bacterial quorum-sensing signal N-decanoyl-L-homoserine lactone.BMC plant biology · 2022Article
- Genome-Wide Identification and Expression Analysis of MAPK Gene Family in Lettuce (International journal of molecular sciences · 2022Article
- TheInternational journal of molecular sciences · 2022Article
- ROS homeostasis mediated by MPK4 and SUMM2 determines synergid cell death.Nature communications · 2022Article
- Regulatory Mechanisms of Mitogen-Activated Protein Kinase Cascades in Plants: More than Sequential Phosphorylation.International journal of molecular sciences · 2022Review
- MAP kinase cascades in plant development and immune signaling.EMBO reports · 2022Review
27 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinesis in plants is achieved by the formation of the cell plate. A pathway that includes mitogen-activated protein (MAP) kinase kinase kinase and MAP kinase kinase (MAPKK) plays a key role in the control of plant cytokinesis. We show here that a MAP kinase, MPK4, is required for the formation of the cell plate in Arabidopsis thaliana. Single mutations in MPK4 caused dwarfism and characteristic defects in cytokinesis, such as immature cell plates, which became much more prominent upon introduction of a mutation in MKK6/ANQ, the MAPKK for cytokinesis, into mpk4. MKK6/ANQ strongly activated MPK4 in protoplasts, and kinase activity of MPK4 was detected in wild-type tissues that contained dividing cells but not in mkk6/anq mutants. Fluorescent protein-fused MPK4 localized to the expanding cell plates in cells of root tips. Expansion of the cell plates in mpk4 root tips appeared to be retarded. The level of MPK11 transcripts was markedly elevated in mpk4 plants, and defects in the mpk4 mpk11 double mutant with respect to growth and cytokinesis were more severe than in the corresponding single mutants. These results indicate that MPK4 is the downstream target of MKK6/ANQ in the regulation of cytokinesis in Arabidopsis and that MPK11 is also involved in cytokinesis.
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