ArticleCancer research2010
Molecular histopathology by spectrally reconstructed nonlinear interferometric vibrational imaging.
Article in Cancer research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Advancing Label-Free Imaging Through CARS Microscopy: From Signal Formation to Biological Interpretation.International journal of molecular sciences · 2026Review
- On the importance of simultaneous label-free multimodal nonlinear optical imaging for biomedical applications.APL photonics · 2025Article
- Mid-infrared hyperspectral microscopy with broadband 1-GHz dual frequency combs.APL photonics · 2024Article
- Temporally optimized and spectrally shaped hyperspectral coherent anti-Stokes Raman scattering microscopy.Optics express · 2024Article
- Simultaneous label-free autofluorescence multi-harmonic microscopy driven by the supercontinuum generated from a bulk nonlinear crystal.Biomedical optics express · 2024Article
- Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine.International journal of molecular sciences · 2022Review
- Real-time and high-throughput Raman signal extraction and processing in CARS hyperspectral imaging.Optics express · 2020Article
- Label-free molecular profiling for identification of biomarkers in carcinogenesis using multimodal multiphoton imaging.Quantitative imaging in medicine and surgery · 2019Article
- Types of advanced optical microscopy techniques for breast cancer research: a review.Lasers in medical science · 2018Review
- Imaging drug uptake by bioorthogonal stimulated Raman scattering microscopy.Chemical science · 2017Article
- Concurrence of extracellular vesicle enrichment and metabolic switch visualized label-free in the tumor microenvironment.Science advances · 2017Article
- Raman Spectroscopic Analysis Reveals Abnormal Fatty Acid Composition in Tumor Micro- and Macroenvironments in Human Breast and Rat Mammary Cancer.Scientific reports · 2016Article
- Stain-free histopathology by programmable supercontinuum pulses.Nature photonics · 2016Article
- Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer.BMC cancer · 2016Article
- Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography.Optics express · 2016Article
- Optical parametrically gated microscopy in scattering media.Optics express · 2014Article
- Enhanced detection of metastatic prostate cancer cells in human plasma with lipid bodies staining.BMC cancer · 2014Article
- Coherent anti-Stokes Raman scattering microscopy: overcoming technical barriers for clinical translation.Journal of biophotonics · 2014Review
- Coherent fiber supercontinuum for biophotonics.Laser & photonics reviews · 2013Article
- Raman imaging at biological interfaces: applications in breast cancer diagnosis.Molecular cancer · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Sensitive assays for rapid quantitative analysis of histologic sections, resected tissue specimens, or in situ tissue are highly desired for early disease diagnosis. Stained histopathology is the gold standard but remains a subjective practice on processed tissue taking from hours to days. We describe a microscopy technique that obtains a sensitive and accurate color-coded image from intrinsic molecular markers. Spectrally reconstructed nonlinear interferometric vibrational imaging can differentiate cancer versus normal tissue sections with greater than 99% confidence interval in a preclinical rat breast cancer model and define cancer boundaries to ± 100 μm with greater than 99% confidence interval, using fresh unstained tissue sections imaged in less than 5 minutes. By optimizing optical sources and beam delivery, this technique can potentially enable real-time point-of-care optical molecular imaging and diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.