ArticleDevelopment (Cambridge, England)2010
Collagen XIXa1 is crucial for motor axon navigation at intermediate targets.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Robo2 Drives Target-Selective Peripheral Nerve Regeneration in Response to Glia-Derived Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish.Frontiers in molecular neuroscience · 2022Article
- Paracrine Role for Somatostatin Interneurons in the Assembly of Perisomatic Inhibitory Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Type XIX collagen: a promising biomarker from the basement membranes.Neural regeneration research · 2020Review
- It is all about the support - The role of the extracellular matrix in regenerating axon guidance.Cell adhesion & migration · 2018Article
- Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish.Nature communications · 2017Article
- Lack of collagen XV is protective after ischemic stroke in mice.Cell death & disease · 2017Article
- Slow Muscle Precursors Lay Down a Collagen XV Matrix Fingerprint to Guide Motor Axon Navigation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Regulation of axonal midline guidance by prolyl 4-hydroxylation in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons.eLife · 2013Article
- Notum homolog plays a novel role in primary motor innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Chondrolectin mediates growth cone interactions of motor axons with an intermediate target.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.Developmental neurobiology · 2011Review
- Netrin signaling breaks the equivalence between two identified zebrafish motoneurons revealing a new role of intermediate targets.PloS one · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During development, motor axons navigate from the spinal cord to their muscle targets in the periphery using stereotyped pathways. These pathways are broken down into shorter segments by intermediate targets where axon growth cones are believed to coordinate guidance cues. In zebrafish stumpy mutants, embryonic development proceeds normally; however, as trunk motor axons stall at their intermediate targets, suggesting that Stumpy is needed specifically for motor axon growth cones to proceed past intermediate targets. Fine mapping and positional cloning revealed that stumpy was the zebrafish homolog of the atypical FACIT collagen collagenXIXa1 (colXIX). colXIX expression was observed in a temporal and spatial pattern, consistent with a role in motor axon guidance at intermediate targets. Knocking down zebrafish ColXIX phenocopied the stumpy phenotype and this morpholino phenotype could be rescued by adding back either mouse or zebrafish colXIX RNA. The stumpy phenotype was also partially rescued in mutants by first knocking down zebrafish ColXIX and adding back colXIX RNA, suggesting that the mutation is acting as a dominant negative. Together, these results demonstrate a novel function for a FACIT collagen in guiding vertebrate motor axons through intermediate targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.