Trial reportCirculation2010
European ancestry as a risk factor for atrial fibrillation in African Americans.
Trial report in Circulation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 6 syntheses or guidelines pooled it, 253 citations in OpenAlex.
- Genetic ancestry and risk of atrial fibrillation in individuals of Black ethnicity in the UK Biobank.Open heart · 2026Pooled it
- Ethnic Contrasts in Stroke Risk Factors and the Atrial Fibrillation Paradox in the United Kingdom: Population-Based Study and Meta-Analysis.Neurology · 2025Pooled it
- Racial and ethnic disparities in arrhythmia care: A call for action.Heart rhythm · 2022Guideline
- Are cardiovascular risk factors also associated with the incidence of atrial fibrillation? A systematic review and field synopsis of 23 factors in 32 population-based cohorts of 20 million participants.Thrombosis and haemostasis · 2017Pooled it
- Guideline
- A common SCN5A variant is associated with PR interval and atrial fibrillation among African Americans.Journal of cardiovascular electrophysiology · 2014Pooled it
- Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study.PLoS medicine · 2018Trial
- Atrial ectopy as a mediator of the association between race and atrial fibrillation.Heart rhythm · 2017Trial
- Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation.Circulation. Cardiovascular genetics · 2015Trial
- Association of Left Atrial Structure and Function with Incident Atrial Fibrillation in Black and White Adults: the ARIC Study.medRxiv : the preprint server for health sciences · 2026Article
- Trends in Atrial Fibrillation-Related Mortality Among Adults With Obesity in the United States From 1999 to 2024.Obesity science & practice · 2026Article
- When Atrial Fibrillation Meets Alcoholic Liver Cirrhosis: Can Direct Oral Anticoagulants Bridge the Therapeutic Gap?Biomedicines · 2026Review
- Review
- Temporal trends and disparities in US mortality with co-listed atrial fibrillation and gastrointestinal bleeding-related mortality, 1999-2020.BMC cardiovascular disorders · 2026Article
- Illicit stimulants and ventricular arrhythmias: a longitudinal cohort study.European heart journal · 2025Article
- Trends in Mortality Related to Atrial Fibrillation and Dementia in Older Adults in the United States: A 2000-2020 Analysis.Journal of cardiovascular electrophysiology · 2025Article
- Atrial fibrillation in Black American patients: A review of genetics, risk factors, and outcomes.Heart rhythm · 2025Review
- Article
- Association of single and multiple cardiometabolic diseases with atrial fibrillation: a prospective cohort study.Open heart · 2025Article
- Atrial fibrillation outcomes in patients from Asia and non-Asia countries: insights from GARFIELD-AF.Open heart · 2025Observational
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite a higher burden of standard atrial fibrillation (AF) risk factors, African Americans have a lower risk of AF than whites. It is unknown whether the higher risk is due to genetic or environmental factors. Because African Americans have varying degrees of European ancestry, we sought to test the hypothesis that European ancestry is an independent risk factor for AF. METHODS AND
resultsWe studied whites (n=4543) and African Americans (n=822) in the Cardiovascular Health Study (CHS) and whites (n=10 902) and African Americans (n=3517) in the Atherosclerosis Risk in Communities (ARIC) Study (n=3517). Percent European ancestry in African Americans was estimated with 1747 ancestry informative markers from the Illumina custom ITMAT-Broad-CARe array. Among African Americans without baseline AF, 120 of 804 CHS participants and 181 of 3517 ARIC participants developed incident AF. A meta-analysis from the 2 studies revealed that every 10% increase in European ancestry increased the risk of AF by 13% (hazard ratio, 1.13; 95% confidence interval, 1.03 to 1.23; P=0.007). After adjustment for potential confounders, European ancestry remained a predictor of incident AF in each cohort alone, with a combined estimated hazard ratio for each 10% increase in European ancestry of 1.17 (95% confidence interval, 1.07 to 1.29; P=0.001). A second analysis using 3192 ancestry informative markers from a genome-wide Affymetrix 6.0 array in ARIC African Americans yielded similar results.
conclusionsEuropean ancestry predicted risk of incident AF. Our study suggests that investigating genetic variants contributing to differential AF risk in individuals of African versus European ancestry will be informative.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.