ArticleAntimicrobial agents and chemotherapy2011
In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH.Nature communications · 2025Article
- Association between Moraxella keratitis and advanced glycation end products.Scientific reports · 2024Article
- Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria.Microorganisms · 2022Review
- β-Lactams against the Fortress of the Gram-PositiveChemical reviews · 2021Review
- Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis.Frontiers in chemistry · 2021Review
- Lipoteichoic Acid Biosynthesis Inhibitors as Potent Inhibitors ofMolecules (Basel, Switzerland) · 2020Article
- Exposure of Staphylococcus aureus to Targocil Blocks Translocation of the Major Autolysin Atl across the Membrane, Resulting in a Significant Decrease in Autolysis.Antimicrobial agents and chemotherapy · 2018Article
- Tunicamycin Mediated Inhibition of Wall Teichoic Acid AffectsFrontiers in microbiology · 2018Article
- Tetracyclic indolines as a novel class of β-lactam-selective resistance-modifying agent for MRSA.European journal of medicinal chemistry · 2017Article
- Envelope Structures of Gram-Positive Bacteria.Current topics in microbiology and immunology · 2017Review
- Staphylococcus aureus Colonization of the Mouse Gastrointestinal Tract Is Modulated by Wall Teichoic Acid, Capsule, and Surface Proteins.PLoS pathogens · 2015Article
- Article
- Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents.Chemistry & biology · 2013Article
- Wall teichoic acids of gram-positive bacteria.Annual review of microbiology · 2013Review
- Wall teichoic acid structure governs horizontal gene transfer between major bacterial pathogens.Nature communications · 2013Article
- Wall teichoic acid protects Staphylococcus aureus from inhibition by Congo red and other dyes.The Journal of antimicrobial chemotherapy · 2012Article
- An antibiotic that inhibits a late step in wall teichoic acid biosynthesis induces the cell wall stress stimulon in Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2012Article
- Divergent responses of different endothelial cell types to infection with Candida albicans and Staphylococcus aureus.PloS one · 2012Article
- Bugs, drugs and chemical genomics.Nature chemical biology · 2011Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Staphylococcus aureus is the leading cause of invasive and superficial human infections, is increasingly antibiotic resistant, and is therefore the target for the development of new antimicrobials. Compounds (1835F03 and targocil) were recently shown to function as bacteriostatic inhibitors of wall teichoic acid (WTA) biosynthesis in S. aureus. To assess the value of targeting WTA biosynthesis in human infection, it was therefore of interest to verify the involvement of WTA in bacterial binding to human corneal epithelial cells (HCECs) and to assess the activities of inhibitors of WTA biosynthesis against clinical isolates of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) from cases of human keratitis. The 1835F03 MIC(90)s were 8 μg/ml for MSSA keratitis isolates and >32 μg/ml for MRSA keratitis isolates. The MIC(90) for the analog of 1835F03, targocil, was 2 μg/ml for both MRSA and MSSA. Targocil exhibited little toxicity at concentrations near the MIC, with increased toxicity occurring at higher concentrations and with longer exposure times. Targocil activity was moderately sensitive to the presence of serum, but it inhibited extracellular and intracellular bacteria in the presence of HCECs better than vancomycin. Targocil-resistant strains exhibited a significantly reduced ability to adhere to HCECs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.