ArticleAntimicrobial agents and chemotherapy2011
Antibacterial action of polyphosphate on Porphyromonas gingivalis.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Review
- Identification of cannabinoid-sensitive and -resistant oral bacteria.Frontiers in microbiology · 2025Article
- Article
- The Physiological Inorganic Polymers Biosilica and Polyphosphate as Key Drivers for Biomedical Materials in Regenerative Nanomedicine.International journal of nanomedicine · 2024Review
- Article
- Proteomic Profiling Reveals Cytotoxic Mechanisms of Action and Adaptive Mechanisms of Resistance inACS omega · 2023Article
- Genomic and phenotypic comparison ofVirulence · 2022Article
- Effectiveness of oral care interventions on malodour in dogs.BMC veterinary research · 2022Article
- Whole genome and RNA sequencing of oral commensal bacterium Streptococcus anginosus subsp. anginosus with vancomycin tolerance.Journal of microbiology (Seoul, Korea) · 2022Article
- Polyphosphate in Antiviral Protection: A Polyanionic Inorganic Polymer in the Fight Against Coronavirus SARS-CoV-2 Infection.Progress in molecular and subcellular biology · 2022Article
- Feasibility of sodium long chain polyphosphate as a potential growth promoter in broilers.Journal of animal science and technology · 2021Article
- Ag-Based Synergistic Antimicrobial Composites. A Critical Review.Nanomaterials (Basel, Switzerland) · 2021Review
- Model systems for studying polyphosphate biology: a focus on microorganisms.Current genetics · 2021Review
- Additive manufacturing of Ti6Al4V alloy via electron beam melting for the development of implants for the biomedical industry.Heliyon · 2021Review
- Antibacterial effects of sodium tripolyphosphate againstJournal of veterinary science · 2019Article
- Effects of Sodium Tripolyphosphate on Oral Commensal and Pathogenic Bacteria.Polish journal of microbiology · 2019Article
- Engineering of a New Bisphosphonate Monomer and Nanoparticles of Narrow Size Distribution for Antibacterial Applications.ACS omega · 2018Article
- A Novel Biomimetic Approach to Repair Enamel Cracks/Carious Damages and to Reseal Dentinal Tubules by Amorphous Polyphosphate.Polymers · 2017Article
- Optimization of a sample processing protocol for recovery of Bacillus anthracis spores from soil.Journal of microbiological methods · 2016Article
- In Vitro Effects of Polyphosphate against Prevotella intermedia in Planktonic Phase and Biofilm.Antimicrobial agents and chemotherapy · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyphosphate [poly(P)] has antibacterial activity against various Gram-positive bacteria. In contrast, Gram-negative bacteria are generally resistant to poly(P). Here, we describe the antibacterial characterization of poly(P) against a Gram-negative periodontopathogen, Porphyromonas gingivalis. The MICs of pyrophosphate (Na(4)P(2)O(7)) and all poly(P) (Na(n + 2)P(n)O(3n + 1); n = 3 to 75) tested for the bacterium by the agar dilution method were 0.24% and 0.06%, respectively. Orthophosphate (Na(2)HPO(4)) failed to inhibit bacterial growth. Poly-P75 was chosen for further study. In liquid medium, 0.03% poly-P75 was bactericidal against P. gingivalis irrespective of the growth phase and inoculum size, ranging from 10(5) to 10(9) cells/ml. UV-visible spectra of the pigments from P. gingivalis grown on blood agar with or without poly-P75 showed that poly-P75 reduced the formation of μ-oxo bisheme by the bacterium. Poly-P75 increased hemin accumulation on the P. gingivalis surface and decreased energy-driven uptake of hemin by the bacterium. The expression of the genes encoding hemagglutinins, gingipains, hemin uptake loci, chromosome replication, and energy production was downregulated, while that of the genes related to iron storage and oxidative stress was upregulated by poly-P75. The transmission electron microscope showed morphologically atypical cells with electron-dense granules and condensed nucleoid in the cytoplasm. Collectively, poly(P) is bactericidal against P. gingivalis, in which hemin/heme utilization is disturbed and oxidative stress is increased by poly(P).
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