ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- A single-cell transcriptomic landscape of mouse testicular aging.Journal of advanced research · 2023Article
- Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019Article
- Nonclassical MHC Ib-restricted CD8+ T Cells Recognize Mycobacterium tuberculosis-Derived Protein Antigens and Contribute to Protection Against Infection.PLoS pathogens · 2016Article
- The burgeoning family of unconventional T cells.Nature immunology · 2015Review
- CXCR3 expression defines a novel subset of innate CD8+ T cells that enhance immunity against bacterial infection and cancer upon stimulation with IL-15.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Expression of the mouse MHC class Ib H2-T11 gene product, a paralog of H2-T23 (Qa-1) with shared peptide-binding specificity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Cutting edge: innate memory CD8+ T cells are distinct from homeostatic expanded CD8+ T cells and rapidly respond to primary antigenic stimuli.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.Immunity · 2013Article
- SAP is required for the development of innate phenotype in H2-M3--restricted Cd8(+) T cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Early events regulating immunity and pathogenesis during Listeria monocytogenes infection.Trends in immunology · 2012Review
- Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection.Infection and immunity · 2012Article
- Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum.Nature immunology · 2012Article
- An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Positive selecting cell type determines the phenotype of MHC class Ib-restricted CD8+ T cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
CD8(+) T cells restricted to MHC class Ib molecules other than H2-M3 have been shown to recognize bacterial Ags. However, the contribution of these T cells to immune responses against bacterial infection is not well defined. To investigate the immune potential of MHC class Ib-restricted CD8(+) T cells, we have generated mice that lack both MHC class Ia and H2-M3 molecules (K(b-/-)D (b-/-)M3(-/-)). The CD8(+) T cells present in K(b-/-)D (b-/-)M3(-/-) mice display an activated surface phenotype and are able to secrete IFN-γ rapidly upon anti-CD3 and anti-CD28 stimulation. Although the CD8(+) T cell population is reduced in K(b-/-)D (b-/-)M3(-/-) mice compared with that in K(b-/-)D (b-/-) mice, this population retains the capacity to expand significantly in response to primary infection with the bacteria Listeria monocytogenes. However, K(b-/-)D (b-/-)M3(-/-) CD8(+) T cells do not expand upon secondary infection, similar to what has been observed for H2-M3-restricted T cells. CD8(+) T cells isolated from Listeria-infected K(b-/-)D (b-/-)M3(-/-) mice exhibit cytotoxicity and secrete proinflammatory cytokines in response to Listeria-infected APCs. These T cells are protective against primary Listeria infection, as Listeria-infected K(b-/-)D (b-/-)M3(-/-) mice exhibit reduced bacterial burden compared with that of infected β(2)-microglobulin-deficient mice that lack MHC class Ib-restricted CD8(+) T cells altogether. In addition, adoptive transfer of Listeria-experienced K(b-/-)D (b-/-)M3(-/-) splenocytes protects recipient mice against subsequent Listeria infection in a CD8(+) T cell-dependent manner. These data demonstrate that other MHC class Ib-restricted CD8(+) T cells, in addition to H2-M3-restricted T cells, contribute to antilisterial immunity and may contribute to immune responses against other intracellular bacteria.
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