Trial reportThe Journal of physiology2011
Plasma pH does not influence the cerebral metabolic ratio during maximal whole body exercise.
Trial report in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Preferential lactate metabolism in the human brain during exogenous and endogenous hyperlactataemia.The Journal of physiology · 2025Article
- Dose of Bicarbonate to Maintain Plasma pH During Maximal Ergometer Rowing and Consequence for Plasma Volume.Frontiers in physiology · 2022Article
- The physiology of rowing with perspective on training and health.European journal of applied physiology · 2020Review
- The Effects of Acute Exercise on Mood, Cognition, Neurophysiology, and Neurochemical Pathways: A Review.Brain plasticity (Amsterdam, Netherlands) · 2017Review
- Fuelling cortical excitability during exercise: what's the matter with delivery?The Journal of physiology · 2016Article
- Cardiovascular control during whole body exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- An Ultra-High Field Magnetic Resonance Spectroscopy Study of Post Exercise Lactate, Glutamate and Glutamine Change in the Human Brain.Frontiers in physiology · 2015Article
- Influence of high altitude on cerebral blood flow and fuel utilization during exercise and recovery.The Journal of physiology · 2014Article
- Fuelling the exercising brain: a regulatory quagmire for lactate metabolism.The Journal of physiology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise lowers the cerebral metabolic ratio of O2 to carbohydrate (glucose+1/2 lactate) and metabolic acidosis appears to promote cerebral lactate uptake. However, the influence of pH on cerebral lactate uptake and, in turn, on the cerebral metabolic ratio during exercise is not known. Sodium bicarbonate (Bicarb, 1 M; 350-500 ml) or an equal volume of normal saline (Sal) was infused intravenously at a constant rate during a '2000 m' maximal ergometer row in six male oarsmen (23±2 years; mean±S.D.). During the Sal trial, pH decreased from 7.41±0.01 at rest to 7.02±0.02 but only to 7.36±0.02 (P <0.05) during the Bicarb trial. Arterial lactate increased to 21.4±0.8 and 32.7±2.3 mM during the Sal and Bicarb trials, respectively (P <0.05). Also, the arterial-jugular venous lactate difference increased from-0.03±0.01 mM at rest to 3.2±0.9 mM (P <0.05) and 3.4±1.4 mM (P <0.05) following the Sal and Bicarb trials, respectively. Accordingly, the cerebral metabolic ratio decreased equally during the Sal and Bicarb trials: from 5.8±0.6 at rest to 1.7±0.1 and 1.8±0.2, respectively. The enlarged blood-buffering capacity after infusion of Bicarb eliminated metabolic acidosis during maximal exercise but that did not affect the cerebral lactate uptake and, therefore, the decrease in the cerebral metabolic ratio.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.