Evidence map›Paper›PMID 21097882›Full record

ArticleNucleic acids research2011

EcoCyc: a comprehensive database of Escherichia coli biology.

Ingrid M Keseler, Julio Collado-Vides, Alberto Santos-Zavaleta, Martin Peralta-Gil, Socorro Gama-Castro, Luis Muñiz-Rascado, César Bonavides-Martinez, Suzanne Paley, Markus Krummenacker, Tomer Altman and 11 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 260 papers.

0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

260 citing papers in PubMed.

  1. Article
  2. Comparative Characterization of σInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Adaptive laboratory evolution ofFrontiers in microbiology · 2026
    Article
  9. Review
  10. Article
  11. The EcoCyc database (2025).EcoSal Plus · 2025
    Review
  12. Article
  13. ImprovedMicrobial genomics · 2025
    Article
  14. Article
  15. Article
  16. The Environment-Dependent Regulatory Landscape of thebioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. UNRAVELING CRP/cAMP-MEDIATED METABOLIC REGULATION INbioRxiv : the preprint server for biology · 2025
    Article
  19. Review
  20. Article

200 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ingrid M KeselerSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA. keseler@ai.sri.com
Julio Collado-Vides
Alberto Santos-Zavaleta
Martin Peralta-Gil
Socorro Gama-Castro
Luis Muñiz-Rascado
César Bonavides-Martinez
Suzanne Paley
Markus Krummenacker
Tomer Altman
Pallavi Kaipa
Aaron Spaulding
John Pacheco
Mario Latendresse
Carol Fulcher
Malabika Sarker
Alexander G Shearer
Amanda Mackie
Ian Paulsen
Robert P Gunsalus
Peter D Karp

Funding

The EcoCyc Model Organism Database for Escherichia coli [SRI Proposal ECU 14-631]U24GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2006 to 2018
$12.3M
Gene Regulation: E.coli Database Integrated ModelingR01GM071962 · NIGMS · CENTER FOR GENOMIC SCIENCES · PI COLLADO-VIDES, JULIO · 2004 to 2011
$2.4M
NIGMS NIH HHS GM071962NIGMS NIH HHS GU24GM077678NIGMS NIH HHS GU24GM077678-20NIGMS NIH HHS R01 GM071962NIGMS NIH HHS U24 GM077678
6 · The paper itself

Abstract

EcoCyc (http://EcoCyc.org) is a comprehensive model organism database for Escherichia coli K-12 MG1655. From the scientific literature, EcoCyc captures the functions of individual E. coli gene products; their regulation at the transcriptional, post-transcriptional and protein level; and their organization into operons, complexes and pathways. EcoCyc users can search and browse the information in multiple ways. Recent improvements to the EcoCyc Web interface include combined gene/protein pages and a Regulation Summary Diagram displaying a graphical overview of all known regulatory inputs to gene expression and protein activity. The graphical representation of signal transduction pathways has been updated, and the cellular and regulatory overviews were enhanced with new functionality. A specialized undergraduate teaching resource using EcoCyc is being developed.

Indexed as

Databases, GeneticBinding SitesEscherichia coli K12Escherichia coli ProteinsGene Expression Regulation, BacterialSignal TransductionSoftwareTranscription FactorsTranscription, GeneticUser-Computer InterfaceEscherichia coli ProteinsTranscription Factors

Identifiers

PMID21097882
PMCPMC3013716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.