ArticleThe Plant cell2010
Amino acid homeostasis modulates salicylic acid-associated redox status and defense responses in Arabidopsis.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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Who cites it
117 citing papers in PubMed, 232 citations in OpenAlex.
- AATRhg1 is a tonoplast protein that alters amino acid, metabolic, and defense responses and nematode resistance.Plant physiology · 2026Article
- Genome-Wide Identification of the Soybean UMAMIT Family and Functional Analysis ofInternational journal of molecular sciences · 2026Article
- Amino Acids as Multifunctional Molecules in Plants: From Fundamental Metabolism to Precision Agriculture.Plants (Basel, Switzerland) · 2026Review
- Cell-type-specific immune programs orchestrate spatial defense in the Arabidopsis leaf epidermis.Nature communications · 2026Article
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- A Cystine Transporter Mediates Nutrient Acquisition and Redox Balance During Wheat Stripe Rust Infection.Molecular plant pathology · 2025Article
- Soybean Cyst Nematode-Resistant Protein AATPlant direct · 2025Article
- AAAP gene family evolution and transcriptional regulation in Eucalyptus grandis under nitrogen, phosphate and boron deficiencies.BMC plant biology · 2025Article
- Iron limitation-induced endophytic Ammoniphilus assemblage promotes root apoplastic iron remobilization by attenuation of salicylic acid pathways.NPJ biofilms and microbiomes · 2025Article
- Genetic dissection of crown rust resistance in oat and the identification of key adult plant resistance genes.The plant genome · 2025Article
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- Super pangenome of Vitis empowers identification of downy mildew resistance genes for grapevine improvement.Nature genetics · 2025Article
- Sugars, Lipids and More: New Insights Into Plant Carbon Sources During Plant-Microbe Interactions.Plant, cell & environment · 2025Review
- Reprogrammed Plant Metabolism During Viral Infections: Mechanisms, Pathways and Implications.Molecular plant pathology · 2025Review
- Growth and physiological response of YuluPlant signaling & behavior · 2024Article
- Transporter-mediated depletion of extracellular proline directly contributes to plant pattern-triggered immunity against a bacterial pathogen.Nature communications · 2024Article
- ComparativeFoods (Basel, Switzerland) · 2024Article
- Priming of Immune System in Tomato by Treatment with Low Concentration of L-Methionine.International journal of molecular sciences · 2024Article
- Response of soybean root exudates and related metabolic pathways to low phosphorus stress.PloS one · 2024Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tight association between nitrogen status and pathogenesis has been broadly documented in plant-pathogen interactions. However, the interface between primary metabolism and disease responses remains largely unclear. Here, we show that knockout of a single amino acid transporter, LYSINE HISTIDINE TRANSPORTER1 (LHT1), is sufficient for Arabidopsis thaliana plants to confer a broad spectrum of disease resistance in a salicylic acid-dependent manner. We found that redox fine-tuning in photosynthetic cells was causally linked to the lht1 mutant-associated phenotypes. Furthermore, the enhanced resistance in lht1 could be attributed to a specific deficiency of its main physiological substrate, Gln, and not to a general nitrogen deficiency. Thus, by enabling nitrogen metabolism to moderate the cellular redox status, a plant primary metabolite, Gln, plays a crucial role in plant disease resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.