ArticleJournal of bacteriology2011
Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 52 citations in OpenAlex.
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- Auxiliary Metabolic Gene Functions in Pelagic and Benthic Viruses of the Baltic Sea.Frontiers in microbiology · 2022Article
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- 7-Deazaguanine modifications protect phage DNA from host restriction systems.Nature communications · 2019Article
- Methylation Warfare: Interaction of Pneumococcal Bacteriophages with Their Host.Journal of bacteriology · 2019Article
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- Still Something to Discover: Novel Insights intoViruses · 2019Article
- Phage puppet masters of the marine microbial realm.Nature microbiology · 2018Review
- Proteome Data Improves Protein Function Prediction in the Interactome ofMolecular & cellular proteomics : MCP · 2018Article
- Two novel temperate bacteriophages infecting Streptococcus pyogenes: Their genomes, morphology and stability.PloS one · 2018Article
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- Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways.RNA biology · 2017Review
- Complete Genome Sequence ofGenome announcements · 2017Article
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- The interactome of Streptococcus pneumoniae and its bacteriophages show highly specific patterns of interactions among bacteria and their phages.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
Streptococcus pneumoniae causes several diseases, including pneumonia, septicemia, and meningitis. Phage Dp-1 is one of the very few isolated virulent S. pneumoniae bacteriophages, but only a partial characterization is currently available. Here, we confirmed that Dp-1 belongs to the family Siphoviridae. Then, we determined its complete genomic sequence of 56,506 bp. It encodes 72 open reading frames, of which 44 have been assigned a function. We have identified putative promoters, Rho-independent terminators, and several genomic clusters. We provide evidence that Dp-1 may be using a novel DNA replication system as well as redirecting host protein synthesis through queuosine-containing tRNAs. Liquid chromatography-mass spectrometry analysis of purified phage Dp-1 particles identified at least eight structural proteins. Finally, using comprehensive yeast two-hybrid screens, we identified 156 phage protein interactions, and this intraviral interactome was used to propose a structural model of Dp-1.
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