ArticleApplied and environmental microbiology2011
Characterization of three lactic acid bacteria and their isogenic ldh deletion mutants shows optimization for YATP (cell mass produced per mole of ATP) at their physiological pHs.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Global diversity of enterococci and description of 18 previously unknown species.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Non-phosphorylating Glyceraldehyde-3-Phosphate Dehydrogenase GapN Is a Potential New Drug Target inFrontiers in microbiology · 2022Article
- PEGylation increases antitumoral activity of arginine deiminase of Streptococcus pyogenes.Applied microbiology and biotechnology · 2022Article
- Inhibitory effect of nitrate/nitrite on the microbial reductive dissolution of arsenic and iron from soils into pore water.Ecotoxicology (London, England) · 2019Article
- Comparative proteomic analysis of four biotechnological strains Lactococcus lactis through label-free quantitative proteomics.Microbial biotechnology · 2019Article
- The Antibacterial Mechanism of Terpinen-4-ol Against Streptococcus agalactiae.Current microbiology · 2018Article
- Deletion of the L-Lactate Dehydrogenase GeneFrontiers in microbiology · 2017Article
- Effects of glucose availability in Lactobacillus sakei; metabolic change and regulation of the proteome and transcriptome.PloS one · 2017Article
- Integrating highly quantitative proteomics and genome-scale metabolic modeling to study pH adaptation in the human pathogenNPJ systems biology and applications · 2016Article
- Loss of Antibiotic Tolerance in Sod-Deficient Mutants Is Dependent on the Energy Source and Arginine Catabolism in Enterococci.Journal of bacteriology · 2015Article
- Using a genome-scale metabolic model of Enterococcus faecalis V583 to assess amino acid uptake and its impact on central metabolism.Applied and environmental microbiology · 2015Article
- Reducing lactate secretion by ldhA Deletion in L-glutamate- producing strain Corynebacterium glutamicum GDK-9.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Enterococcus faecalis grows on ascorbic acid.Applied and environmental microbiology · 2013Article
- Redox balance via lactate dehydrogenase is important for multiple stress resistance and virulence in Enterococcus faecalis.Infection and immunity · 2013Article
- Regulation of the activity of lactate dehydrogenases from four lactic acid bacteria.The Journal of biological chemistry · 2013Article
- Organism-adapted specificity of the allosteric regulation of pyruvate kinase in lactic acid bacteria.PLoS computational biology · 2013Article
- Engineering a cyanobacterial cell factory for production of lactic acid.Applied and environmental microbiology · 2012Article
- Effects of the ERES pathogenicity region regulator Ralp3 on Streptococcus pyogenes serotype M49 virulence factor expression.Journal of bacteriology · 2012Article
- Growth rate-dependent control in Enterococcus faecalis: effects on the transcriptome and proteome, and strong regulation of lactate dehydrogenase.Applied and environmental microbiology · 2012Article
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9 authors.
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Abstract
Several lactic acid bacteria use homolactic acid fermentation for generation of ATP. Here we studied the role of the lactate dehydrogenase enzyme on the general physiology of the three homolactic acid bacteria Lactococcus lactis, Enterococcus faecalis, and Streptococcus pyogenes. Of note, deletion of the ldh genes hardly affected the growth rate in chemically defined medium under microaerophilic conditions. However, the growth rate was affected in rich medium. Furthermore, deletion of ldh affected the ability for utilization of various substrates as a carbon source. A switch to mixed acid fermentation was observed during glucose-limited continuous growth and was dependent on the growth rate for S. pyogenes and on the pH for E. faecalis. In S. pyogenes and L. lactis, a change in pH resulted in a clear change in Y(ATP) (cell mass produced per mole of ATP). The pH that showed the highest Y(ATP) corresponded to the pH of the natural habitat of the organisms.
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