Evidence map›Paper›PMID 21095821›Full record

ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2010

Multiscale imaging of the human heart: Building the foundation for human systems physiology and translational medicine.

Igor R Efimov, Vadim V Fedorov, Alexey Glukhov, Qing Lou, Christina Ambrosi, Deborah Janks, William J Hucker, Thomas Kurian, Richard B Schuessler, Nader Moazami

Open access · greenAbstract read
In one paragraph

Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Human cardiac systems electrophysiology and arrhythmogenesis: iteration of experiment and computation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2014
    Review
  4. Article
  5. Article
  6. Remodeling of calcium handling in human heart failure.Advances in experimental medicine and biology · 2012
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Igor R EfimovDepartment of Biomedical Engineering, Washington University in St. Louis, MO 63130, USA. igor@wustl.edu
Vadim V Fedorov
Alexey Glukhov
Qing Lou
Christina Ambrosi
Deborah Janks
William J Hucker
Thomas Kurian
Richard B Schuessler
Nader Moazami
Washington University in St. Louis · US

Funding

ARRHYTHMOGENIC REMODELING IN HUMAN HEART FAILURER01HL114395 · NHLBI · WASHINGTON UNIVERSITY · PI EFIMOV, IGOR R · 2012 to 2015
$2.1M
STRUCTURE/FUNCTION OF THE PACEMAKING AND CONDUCTION SYSTEM OF THE HEARTR01HL085369 · NHLBI · WASHINGTON UNIVERSITY · PI EFIMOV, IGOR R · 2008 to 2011
$1.5M
NHLBI NIH HHS R01 HL0085369NHLBI NIH HHS R01 HL085369NHLBI NIH HHS R01 HL114395
6 · The paper itself

Abstract

The development of human cardiovascular systems physiology is inhibited by the lack of multiscale functional physiological data, which represents human heart physiology at the molecular, cellular, tissue, organ, and system levels. We have developed an experimental approach to study explanted human hearts in vitro at multiple physiological scales with a wide array of imaging modalities. This approach has already yielded data indicating significant differences between animal models of diseases and actual human heart disease. Our data provides a quantitative foundation for multiscale physiological models of the cardiovascular system and will allow improvement in translation of medical technology and pharmacology from animal models to therapy.

Indexed as

Cardiovascular Physiological PhenomenaTranslational Research, BiomedicalCalciumExcitation Contraction CouplingFemaleHeartHeart TransplantationHumansImaging, Three-DimensionalMaleMembrane PotentialsCalcium

Identifiers

PMID21095821
PMCPMC3748588
OpenAlexW2078400836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.