Trial reportAmerican heart journal2010
Serum 25-hydroxyvitamin D concentration is associated with functional capacity in older adults with heart failure.
Trial report in American heart journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- A randomized controlled trial of high dose vitamin D3 in patients with heart failure.JACC. Heart failure · 2013Trial
- Vitamin D in Cardiovascular Medicine: From Molecular Mechanisms to Clinical Translation.Nutrients · 2026Review
- The Association between Serum Levels of 25[OH]D, Body Weight Changes and Body Composition Indices in Patients with Heart Failure.Journal of clinical medicine · 2020Article
- An Empirical Study on the Effect of Short-Term Regular Vitamin D3 Supplement Therapy on Blood Pressure and Exercise Tolerance in Heart Failure Patients.Clinical nutrition research · 2020Article
- Article
- Micronutrient Deficiency Independently Predicts Time to Event in Patients With Heart Failure.Journal of the American Heart Association · 2018Article
- Vitamin D measurement and effect on outcome in a cohort of patients with heart failureEndocrine connections · 2018Article
- Hypovitaminosis D in patients with heart failure: effects on functional capacity and patients' survival.Endocrine · 2017Article
- Vitamin D and Heart Failure.Current heart failure reports · 2017Review
- Vitamin D and its effects on cardiovascular diseases: a comprehensive review.The Korean journal of internal medicine · 2016Review
- Effect of vitamin D supplementation on cardiovascular disease risk factors and exercise performance in healthy participants: a randomized placebo-controlled preliminary study.Therapeutic advances in endocrinology and metabolism · 2016Article
- Clinical and laboratory determinants of low serum level of 25-hydroxyvitamin D during escalation of pharmacotherapy in heart failure patients.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2015Article
- Vitamin D insufficiency is associated with lower physical function in patients with heart failure and diabetes.Journal of diabetes research · 2014Article
- Vitamin D and the cardiovascular system.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Review
- Article
- Vitamin D in chronic heart failure.Current heart failure reports · 2011Review
- Vitamin D Deficiency Is a Predictor of Mortality in Elderly with Chronic Heart Failure.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundVitamin D is a fat-soluble hormone necessary for calcium homeostasis. Recently, studies have demonstrated that vitamin D may be important to the health of the cardiovascular system.
methodsAdults ≥ 50 years of age with heart failure were recruited for assessment of serum 25-hydroxyvitamin D (25OHD) concentrations. Cardiopulmonary exercise testing was used to assess functional capacity. Proximal muscle strength was evaluated with a Biodex isokinetic dynamometer [corrected] (Biodex, Shirley, NY), and health status was assessed with the Kansas City Cardiomyopathy Questionnaire. Univariate associations between physical performance and health status measures and 25OHD followed by a linear regression model were used to study associations, adjusting for other potential explanatory variables.
resultsForty adults 67.8 ± 10.9 years of age (55% women and 57.5% African American) with mean ejection fraction 40% were analyzed (New York Heart Association class II in 70% and class III in 30%). Comorbidities included 77.5% hypertension and 47.5% diabetes. The mean 25OHD concentration was 18.5 ± 9.1 ng/mL, and mean peak Vo₂, 14 ± 4 mL/kg/min. In univariate regression analysis, 25OHD was positively associated with peak Vo₂ (P = .045). Multivariable regression analysis sustained positive association between 25OHD and peak Vo₂ (P = .044) after adjusting for age, race, and respiratory exchange ratio (adjusted R² = 0.32). Association between proximal muscle strength with the 25OHD concentration was not significant. The Kansas City Cardiomyopathy Questionnaire physical limitation domain score was negatively associated with 25OHD (P = .04) but was not sustained in multivariable analysis.
conclusions25-Hydroxyvitamin D may be an important marker or modulator of functional capacity in patients with heart failure. Randomized controlled trials are needed to assess the effect of vitamin D repletion on functional performance.
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