ArticleJournal of autoimmunity2011
Limited sufficiency of antigen presentation by dendritic cells in models of central nervous system autoimmunity.
Article in Journal of autoimmunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Turncoat antibodies unmasked in a model of autoimmune demyelination: From biology to therapy.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Role of dendritic cells in spinal cord injury.CNS neuroscience & therapeutics · 2024Review
- Transient Receptor Potential Vanilloid 4-Dependent Microglial Function in Myelin Injury and Repair.International journal of molecular sciences · 2023Article
- Role of DAMPs and cell death in autoimmune diseases: the example of multiple sclerosis.Genes and immunity · 2023Review
- Antigen-specific depletion of CD4Science immunology · 2022Article
- SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity.Journal of neuroinflammation · 2022Article
- Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunity.Journal of neuroinflammation · 2021Article
- Noradrenaline modulates CD4+ T cell priming in rat experimental autoimmune encephalomyelitis: a role for the αImmunologic research · 2019Article
- B Cell-Mediated Antigen Presentation through MHC Class II Is Dispensable for Atherosclerosis Progression.ImmunoHorizons · 2019Article
- Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain.Central-European journal of immunology · 2019Article
- Antigen-presenting cell diversity for T cell reactivation in central nervous system autoimmunity.Journal of molecular medicine (Berlin, Germany) · 2018Review
- MicroRNA signature of central nervous system-infiltrating dendritic cells in an animal model of multiple sclerosis.Immunology · 2018Article
- Article
- Functional connectivity alterations in a murine model of optic neuritis.Experimental neurology · 2017Article
- Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity.Scientific reports · 2017Article
- OGR1/GPR68 Modulates the Severity of Experimental Autoimmune Encephalomyelitis and Regulates Nitric Oxide Production by Macrophages.PloS one · 2016Article
- Differential roles of resident microglia and infiltrating monocytes in murine CNS autoimmunity.Seminars in immunopathology · 2015Review
- B cell antigen presentation is sufficient to drive neuroinflammation in an animal model of multiple sclerosis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Role and therapeutic value of dendritic cells in central nervous system autoimmunity.Cell death and differentiation · 2015Review
- Optic Neuritis: A Model for the Immuno-pathogenesis of Central Nervous System Inflammatory Demyelinating Diseases.Current immunology reviews · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Experimental autoimmune encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS), is dependent upon the activation and effector functions of autoreactive CD4 T cells. Multiple interactions between CD4 T cells and major histocompatibility class II (MHCII)+ antigen presenting cells (APCs) must occur in both the periphery and central nervous system (CNS) to elicit autoimmunity. The identity of the MHCII+ APCs involved throughout this process remains in question. We investigated which APC in the periphery and CNS mediates disease using transgenic mice with MHCII expression restricted to dendritic cells (DCs). MHCII expression restricted to DCs results in normal susceptibility to peptide-mediated EAE. Indeed, radiation-sensitive bone marrow-derived DCs were sufficient for all APC functions during peptide-induced disease. However, DCs alone were inefficient at promoting disease after immunization with the myelin protein myelin oligodendrocyte glycoprotein (MOG), even in the presence of MHCII-deficient B cells. Consistent with a defect in disease induction following protein immunization, antigen presentation by DCs alone was incapable of mediating spontaneous optic neuritis. These results indicate that DCs are capable of perpetuating CNS-targeted autoimmunity when antigens are readily available, but other APCs are required to efficiently initiate pathogenic cognate CD4 T cell responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.