ArticlePsychoneuroendocrinology2011
Effects of social isolation on mRNA expression for corticotrophin-releasing hormone receptors in prairie voles.
Article in Psychoneuroendocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Astrocytes mediate a positive feedback loop for oxytocin.bioRxiv : the preprint server for biology · 2026Article
- Research progress on chronic stress stimulation and gastric cancer metastasis.Discover oncology · 2025Review
- Comparative impact of social isolation on mortality in adults aged 40 years and above with versus without metabolic syndrome: evidence from two large cohorts in the U.S. and U.K.Population health metrics · 2025Article
- Voluntary exercise is a moderately effective mitigator of chronic social isolation stress in two female rodent models.Physiology & behavior · 2025Article
- The effects of social loss and isolation on partner odor investigation and dopamine and oxytocin receptor expression in female prairie voles.Neuropharmacology · 2025Article
- The effect of acute social isolation on neural molecular responses in components of the social decision-making network.BMC genomics · 2024Article
- The effects of momentary loneliness and COVID-19 stressors on hypothalamic-pituitary adrenal (HPA) axis functioning: A lockdown stage changes the association between loneliness and salivary cortisol.Psychoneuroendocrinology · 2022Article
- Dynamic influences on the neural encoding of social valence.Nature reviews. Neuroscience · 2022Review
- Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives.Frontiers in behavioral neuroscience · 2022Review
- Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system.Psychoneuroendocrinology · 2022Review
- Loneliness: An Immunometabolic Syndrome.International journal of environmental research and public health · 2021Review
- HIV-1 Tat and morphine decrease murine inter-male social interactions and associated oxytocin levels in the prefrontal cortex, amygdala, and hypothalamic paraventricular nucleus.Hormones and behavior · 2021Article
- Social isolation alters behavior, the gut-immune-brain axis, and neurochemical circuits in male and female prairie voles.Neurobiology of stress · 2020Article
- Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus.Scientific reports · 2020Article
- Is Oxytocin "Nature's Medicine"?Pharmacological reviews · 2020Review
- Potential Neurochemical and Neuroendocrine Effects of Social Distancing Amidst the COVID-19 Pandemic.Frontiers in endocrinology · 2020Article
- Long-Term Impact of Social Isolation and Molecular Underpinnings.Frontiers in genetics · 2020Review
- Neural mechanisms of social homeostasis.Annals of the New York Academy of Sciences · 2019Review
- Chronic Isolation Stress Affects Subsequent Crowding Stress-Induced Brain Nitric Oxide Synthase (NOS) Isoforms and Hypothalamic-Pituitary-Adrenal (HPA) Axis Responses.Neurotoxicity research · 2019Article
- Oxytocin administration prevents cellular aging caused by social isolation.Psychoneuroendocrinology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have demonstrated that various type of stressors modulate messenger ribonucleic acid (mRNA) for type 1 corticotropin-releasing hormone (CRH) receptor (CRH-R1 mRNA) and type 2 CRH receptor (CRH-R2 mRNA). The purpose of this study was to explore the effect of social isolation stress of varying durations on the CRH, CRH-R1 and CRH-R2 mRNAs expression in the hypothalamus, hippocampus and pituitary of socially monogamous female and male prairie voles (Microtus ochrogaster). Isolation for 1h (single isolation) or 1h of isolation every day for 4 weeks (repeated isolation) was followed by a significant increase in plasma corticosterone levels. Single or repeated isolation increased hypothalamic CRH mRNA expression, but no changes in CRH-R1 mRNA in the hypothalamus were observed. Continuous isolation for 4 weeks (chronic isolation) showed no effect on hypothalamic CRH or CRH-R1 mRNAs in female or male animals. However, hypothalamic CRH-R2 mRNA was significantly reduced in voles exposed to chronic isolation. Single or repeated isolation, but not chronic isolation, significantly increased CRH-R1 mRNA and decreased CRH-R2 mRNA in the pituitary. Despite elevated CRH mRNA expression, CRH-R1 and CRH-R2 mRNAs were not modulated in the hippocampus following single or repeated isolation. Although, chronic isolation did not affect hippocampal CRH or CRH-R1 mRNAs, it did increase CRH-R2 mRNA expression in females and males. The results of the present study in prairie voles suggest that social isolation has receptor subtype and species-specific consequences for the modulation of gene expression for CRH and its receptors in brain and pituitary. Previous studies have revealed a female-biased increase in oxytocin in response to chronic isolation; however, we did not find a sex difference in CRH or its receptors following single, repeated or chronic social isolation, suggesting that sexually dimorphic processes beyond the CRH system, possibly involving vasopressin, might explain this difference.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.