Evidence map›Paper›PMID 21094986›Full record

ReviewThrombosis research2011

Platelets as initiators and mediators of inflammation at the vessel wall.

Guanfang Shi, Craig N Morrell

Abstract readReview
In one paragraph

Review in Thrombosis research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 79 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Platelet P2YBritish journal of pharmacology · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Construction and efficiency analysis of prediction model for venous thromboembolism risk in the elderly after hip fracture.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  13. Frontiers in pharmacology · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Myeloid cells as therapeutic targets in neuroinflammation after stroke: Specific roles of neutrophils and neutrophil-platelet interactions.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Guanfang ShiAab Cardiovascular Research Institute, University of Rochester School of Medicine & Dentistry, 601 Elmwood Avenue, Box CVRI, Rochester, New York 14642, USA.
Craig N Morrell
University of Rochester · US

Funding

The Role of Platelets in Alloantibody Mediated Transplant RejectionR01HL093179 · NHLBI · UNIVERSITY OF ROCHESTER · PI MORRELL, CRAIG N · 2008 to 2012
$2.2M
Glutamate Mediates Platelet Activation through an Ionotropic Glutamate ReceptorR01HL094547 · NHLBI · UNIVERSITY OF ROCHESTER · PI MORRELL, CRAIG N · 2009 to 2012
$1.6M
NHLBI NIH HHS R01 HL093179NHLBI NIH HHS R01 HL094547
6 · The paper itself

Abstract

Platelets are dynamic cells with activities that extend beyond thrombosis including an important role in initiating and sustaining vascular inflammation. A role for platelets has been described in many physiologic and pathophysiologic processes such as atherosclerosis, stem cell trafficking, tumor metastasis, and arthritis. Platelet activation at sites of an intact inflamed endothelium contributes to vascular inflammation and vascular wall remodeling. Platelets secrete a wide array of preformed and synthesized inflammatory mediators upon activation that can exert significant local and systemic effects. This review will focus on the role of platelet derived mediators in vascular inflammation and vascular wall remodeling.

Indexed as

AnimalsAtherosclerosisBlood PlateletsHumansInflammationMiceVascular Diseases

Identifiers

PMID21094986
PMCPMC3068230
OpenAlexW2154503733

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.