Evidence map›Paper›PMID 21094927›Full record

ReviewImmunology and allergy clinics of North America2011

Biobehavioral influences on cancer progression.

Erin S Costanzo, Anil K Sood, Susan K Lutgendorf

Abstract readReview
In one paragraph

Review in Immunology and allergy clinics of North America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 123 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Psychosocial telephone counseling for survivors of cervical cancer: results of a randomized biobehavioral trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015
    Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. A Neighborhood-Level Hispanic Paradox: The Interaction among Hispanic Density, Neighborhood Disadvantage, and Survival in Patients with Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Association Between Neighborhood Opportunity, Allostatic Load, and All-Cause Mortality in Patients With Breast Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Erin S CostanzoDepartment of Psychiatry, Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA. ecostanzo@wisc.edu
Anil K Sood
Susan K Lutgendorf
The University of Texas MD Anderson Cancer Center · USUniversity of Iowa · USUniversity of Wisconsin Carbone Cancer Center · US

Funding

Institutional Clinical and Translational Science Award (UW-Madison)KL2RR025012 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$11.1M
Ovarian Cancer: Mechanisms of Neuroendocrine RegulationR01CA109298 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOOD, ANIL K · 2005 to 2017
$4.5M
Biobehavioral Influences and the Ovarian Tumor MicroenvironmentR01CA140933 · NCI · UNIVERSITY OF IOWA · PI LUTGENDORF, SUSAN K · 2009 to 2013
$2.8M
Tumor metastasis: Biobehavioral mechanismsR01CA110793 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOOD, ANIL K · 2004 to 2009
$2.1M
Biobehavioral-Cytokine Interactions:Ovarian Cancer(RMI)R01CA104825 · NCI · UNIVERSITY OF IOWA · PI LUTGENDORF, SUSAN K · 2003 to 2007
$1.8M
Predictors of Optimal Immune Reconstitution in Stem Cell Transplant PatientsR21CA133343 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI COSTANZO, ERIN · 2010 to 2011
$350k
NCI NIH HHS P50 CA083693NCI NIH HHS R01 CA104825NCI NIH HHS R01 CA109298NCI NIH HHS R01 CA110793NCI NIH HHS R01 CA140933NCI NIH HHS R21 CA133343NCRR NIH HHS KL2 RR0205012NCRR NIH HHS KL2 RR025012
6 · The paper itself

Abstract

This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. Behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiologic pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell signaling pathways are described. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Behavioral and pharmacologic interventions with the potential to alter these biobehavioral pathways for patients with cancer are discussed.

Indexed as

InflammationStress, PsychologicalDepressionDisease ProgressionHumansHypothalamo-Hypophyseal SystemImmunosuppression TherapyNeoplasmsNeovascularization, PhysiologicPituitary-Adrenal SystemResilience, PsychologicalSocial SupportSympathetic Nervous System

Identifiers

PMID21094927
PMCPMC3011980
OpenAlexW2101153293

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.