Evidence map›Paper›PMID 21094924›Full record

ReviewImmunology and allergy clinics of North America2011

Stressor-induced alterations of adaptive immunity to vaccination and viral pathogens.

Nicole D Powell, Rebecca G Allen, Amy R Hufnagle, John F Sheridan, Michael T Bailey

Open access · greenAbstract readReview
In one paragraph

Review in Immunology and allergy clinics of North America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Influenza-Mediated Lung Infection Models.Methods in molecular biology (Clifton, N.J.) · 2019
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nicole D PowellDivision of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
Rebecca G Allen
Amy R Hufnagle
John F Sheridan
Michael T Bailey
Institute for Behavioral Medicine · USThe Ohio State University · US

Funding

Comprehensive Training in Oral &Craniofacial SciencesT32DE014320 · NIDCR · OHIO STATE UNIVERSITY · PI SHERIDAN, JOHN F · 2001 to 2022
$10.2M
STRESS-INDUCED IMMUNOSUPPRESSION OF ANTIVIRAL IMMUNITYR01MH046801 · NIMH · OHIO STATE UNIVERSITY · PI SHERIDAN, JOHN F · 1991 to 2008
$2.7M
NIDCR NIH HHS T32 DE014320NIMH NIH HHS R01 MH046801
6 · The paper itself

Abstract

The stress response influences the immune system, and studies in laboratory animals indicate that the response to stress significantly reduces resistance to infectious challenge. Only a few studies, however, have determined the impact of the stress response on human susceptibility to infectious challenge due, in part, to the difficulties of using live, replicating pathogens in human research. As a result, many studies have assessed the immune response to vaccination as a surrogate for the immune response to an infectious challenge. Thus, much is known about how the stress response influences adaptive immunity, and memory responses, to vaccination. These studies have yielded data concerning the interactions of the nervous and immune systems and have provided important information for clinicians administering vaccines to susceptible populations. This review provides a brief overview of the immune response to commonly used vaccines and the impact that stress can have on vaccine-specific immunity.

Indexed as

Adaptive ImmunityImmune ToleranceStress, PsychologicalAnimalsCD4-Positive T-LymphocytesHumansInfluenza VaccinesMiceVaccinationVaccinesVirus DiseasesInfluenza VaccinesVaccines

Identifiers

PMID21094924
PMCPMC3339561
OpenAlexW2070740233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.