Evidence map›Paper›PMID 21094677›Full record

ReviewMolecular and cellular endocrinology2011

Adrenocortical stem and progenitor cells: unifying model of two proposed origins.

Michelle A Wood, Gary D Hammer

Abstract readReview
In one paragraph

Review in Molecular and cellular endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 73 citations in OpenAlex.

  1. Trial
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  14. Development of adrenal cortex zonation.Endocrinology and metabolism clinics of North America · 2015
    Review
  15. Article
  16. Article
  17. Review
  18. Hedgehog signaling and steroidogenesis.Annual review of physiology · 2015
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michelle A WoodUniversity of Michigan, 109 Zina Pitcher Place, 1528 Biomedical Science Research Building, Ann Arbor, MI 48109, United States.
Gary D Hammer
University of Michigan–Ann Arbor · US

Funding

Mechanisms of Adrenal DifferentiationR01DK062027 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARY D. HAMMER · 2004 to 2026
$8.0M
TRAINING PROGRAM IN ENDOCRINOLOGY AND METABOLISM.T32DK007245 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RICHARD J. AUCHUS · 1986 to 2026
$7.2M
Wnt-responsive adrenocortical cells in organ maintenance and cancerR01CA134606 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMMER, GARY D. · 2010 to 2014
$1.4M
NCI NIH HHS CA134606NCI NIH HHS R01 CA134606NIDDK NIH HHS DK062027NIDDK NIH HHS R01 DK062027NIDDK NIH HHS T32 DK007245NIDDK NIH HHS T32 DK07245
6 · The paper itself

Abstract

The origins of our understanding of the cellular and molecular mechanisms by which signaling pathways and downstream transcription factors coordinate the specification of adrenocortical cells within the adrenal gland have arisen from studies on the role of Sf1 in steroidogenesis and adrenal development initiated 20 years ago in the laboratory of Dr. Keith Parker. Adrenocortical stem/progenitor cells have been predicted to be undifferentiated and quiescent cells that remain at the periphery of the cortex until needed to replenish the organ, at which time they undergo proliferation and terminal differentiation. Identification of these stem/progenitor cells has only recently been explored. Recent efforts have examined signaling molecules, including Wnt, Shh, and Dax1, which may coordinate intricate lineage and signaling relationships between the adrenal capsule (stem cell niche) and underlying cortex (progenitor cell pool) to maintain organ homeostasis in the adrenal gland.

Indexed as

Cell LineageModels, BiologicalAdrenal CortexAnimalsCell DifferentiationHumansOrganogenesisStem Cells

Identifiers

PMID21094677
PMCPMC3397472
OpenAlexW1998979804

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.