Evidence map›Paper›PMID 21094258›Full record

Trial reportNeuroImage2012

TDCS guided using fMRI significantly accelerates learning to identify concealed objects.

Vincent P Clark, Brian A Coffman, Andy R Mayer, Michael P Weisend, Terran D R Lane, Vince D Calhoun, Elaine M Raybourn, Christopher M Garcia, Eric M Wassermann

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02780739 (An Integrative System for Enhancing Fluid Intelligence), which is not on this map. Cited by 107 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02780739 nacompletednot on this mapstarted 2014, after this paper: background citation

An Integrative System for Enhancing Fluid Intelligence (Gf) Through Human Cognitive Activity, Fitness, High-definition Transcranial Direct-current Brain Stimulation (HD-tDCS), and Nutritional Intervention

TypeinterventionalSponsorUniversity of Illinois at Urbana-ChampaignRan2014 to 2014Enrolled521ConditionsCognitive Ability, GeneralArmsCognitive Training - 48 sessions, Fitness, Active Control, active tDCS, sham tDCS
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Vincent P ClarkMind Research Network, Albuquerque, NM 87106, USA. vclark@unm.edu
Brian A Coffman
Andy R Mayer
Michael P Weisend
Terran D R Lane
Vince D Calhoun
Elaine M Raybourn
Christopher M Garcia
Eric M Wassermann

Funding

Electrophysiological Probes And Treatments In Neurobehavioral DisordersZIANS002977 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WASSERMANN, ERIC M · 2009 to 2025
$14.6M
Intramural NIH HHS ZIA NS002977
6 · The paper itself

Abstract

The accurate identification of obscured and concealed objects in complex environments was an important skill required for survival during human evolution, and is required today for many forms of expertise. Here we used transcranial direct current stimulation (tDCS) guided using neuroimaging to increase learning rate in a novel, minimally guided discovery-learning paradigm. Ninety-six subjects identified threat-related objects concealed in naturalistic virtual surroundings used in real-world training. A variety of brain networks were found using functional magnetic resonance imaging (fMRI) data collected at different stages of learning, with two of these networks focused in right inferior frontal and right parietal cortex. Anodal 2.0 mA tDCS performed for 30 min over these regions in a series of single-blind, randomized studies resulted in significant improvements in learning and performance compared with 0.1 mA tDCS. This difference in performance increased to a factor of two after a one-hour delay. A dose-response effect of current strength on learning was also found. Taken together, these brain imaging and stimulation studies suggest that right frontal and parietal cortex are involved in learning to identify concealed objects in naturalistic surroundings. Furthermore, they suggest that the application of anodal tDCS over these regions can greatly increase learning, resulting in one of the largest effects on learning yet reported. The methods developed here may be useful to decrease the time required to attain expertise in a variety of settings.

Indexed as

Electric StimulationBrainBrain MappingHumansLearningMagnetic Resonance ImagingSingle-Blind Method

Identifiers

PMID21094258
PMCPMC3387543

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.