ArticleExperimental gerontology2011
Impairment of IGF-I expression and anabolic signaling following ischemia/reperfusion in skeletal muscle of old mice.
Article in Experimental gerontology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- An integrated drug repositioning analysis identifies rosiglitazone as a treatment for sarcopenia.Communications biology · 2026Article
- Vascular dysfunction as a potential culprit of sarcopenia.Experimental gerontology · 2021Review
- Crosstalk of Hedgehog and mTORC1 Pathways.Cells · 2020Review
- Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle.Antioxidants (Basel, Switzerland) · 2019Article
- Article
- Controlled delivery of SDF-1α and IGF-1: CXCR4(+) cell recruitment and functional skeletal muscle recovery.Biomaterials science · 2015Article
- Anti-inflammatory macrophages improve skeletal muscle recovery from ischemia-reperfusion.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Interaction between insulin-like growth factor-1 and atherosclerosis and vascular aging.Frontiers of hormone research · 2014Review
- The therapeutic potential of IGF-I in skeletal muscle repair.Trends in endocrinology and metabolism: TEM · 2013Review
- Aging, atherosclerosis, and IGF-1.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Controlled release of IGF-I from a biodegradable matrix improves functional recovery of skeletal muscle from ischemia/reperfusion.Biotechnology and bioengineering · 2012Article
- Expression of insulin-like growth factor 1 isoforms in the rabbit oculomotor system.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2011Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
With the advancement of age, skeletal muscle undergoes a progressive decline in mass, function, and regenerative capacity. Previously, our laboratory has reported an age-reduction in recovery and local induction of IGF-I gene expression with age following tourniquet (TK)-induced skeletal muscle ischemia/reperfusion (I/R). In this study, young (6 mo) and old (24-28 mo) mice were subjected to 2h of TK-induced ischemia of the hindlimb followed by 1, 3, 5, or 7 days of reperfusion. Real time-PCR analysis revealed clear age-related reductions and temporal alterations in the expression of IGF-I and individual IGF-I Ea and Eb splice variants. ELISA verified a reduction of IGF-I peptide with age following 7 day recovery from TK. Western blotting showed that the phosphorylation of Akt, mTOR, and FoxO3, all indicators of anabolic activity, were reduced in the muscles of old mice. These data indicate that an age-related impairment of IGF-I expression and intracellular signaling does exist following injury, and potentially has a role in the impaired recovery of skeletal muscle with age.
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Registered trials
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