ArticleOphthalmology2011
A standardized grading system for scleritis.
Article in Ophthalmology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03465111 (An Open Label, Multi-centered, Randomized Phase 2 Study to Evaluate the Safety, Tolerability and Bioactivity of Subcutaneous ACTH GeL in PAtients With Scleritis), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Open Label, Multi-centered, Randomized Phase 2 Study to Evaluate the Safety, Tolerability and Bioactivity of Subcutaneous ACTH GeL in PAtients With Scleritis: The ATLAS Study
Who cites it
32 citing papers in PubMed, 98 citations in OpenAlex.
- Association between advanced glycation end products and uveitis/scleritis activity in patients with active immune-mediated ocular inflammatory diseases.International ophthalmology · 2024Trial
- Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis: Results of a Phase I/II Clinical Trial.American journal of ophthalmology · 2016Trial
- Subconjunctival sirolimus in the treatment of autoimmune non-necrotizing anterior scleritis: results of a phase I/II clinical trial.American journal of ophthalmology · 2015Trial
- Successful Ocular Structural Restoration of Aggressive Necrotizing Sclerouveitis Following Pterygium Excision: Infectious, Autoimmune, or Both?Research square · 2026Article
- Sequential ocular surgeries and multimodal immunosuppression for bilateral, medically refractory seronegative scleritis with severe peripheral corneal stromal thinning: a case report.BMC ophthalmology · 2026Article
- Wide-field fluorescein angiography findings in active anterior scleritis.Journal of ophthalmic inflammation and infection · 2024Article
- Efficacy and tolerability of subcutaneous repository corticotropin injection in refractory ocular inflammatory diseases.Journal of ophthalmic inflammation and infection · 2024Article
- Visual Morbidity and Outcomes of Scleritis Associated with Intraocular Inflammation Compared to Isolated Scleritis.Ocular immunology and inflammation · 2024Article
- Efficacy and safety of Janus kinase inhibitors in non-infectious inflammatory ocular diseases: a prospective cohort study from the international AIDA network registries.Frontiers in medicine · 2024Article
- Corneal nerve changes in herpes zoster ophthalmicus: a prospective longitudinal in vivo confocal microscopy study.Eye (London, England) · 2023Article
- Optical Coherence Tomography: Focus on the Pathology of Macula in Scleritis Patients.Journal of clinical medicine · 2023Article
- Outcomes of Escalating Immunosuppressive Treatments for Recalcitrant Noninfectious Posterior Scleritis.Ophthalmology and therapy · 2022Article
- Clinical patterns and risk factors in scleritis: a multicentric study in Colombia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Adalimumab plus Conventional Therapy versus Conventional Therapy in Refractory Non-Infectious Scleritis.Journal of clinical medicine · 2022Article
- Development and implementation of the AIDA International Registry for patients with Behçet's disease.Internal and emergency medicine · 2022Article
- Development and Implementation of the AIDA International Registry for Patients with Non-Infectious Scleritis.Ophthalmology and therapy · 2022Article
- Development and Implementation of the AIDA International Registry for Patients with Non-Infectious Uveitis.Ophthalmology and therapy · 2022Article
- Methotrexate for chronic non-necrotizing anterior scleritis in Chinese patients.International journal of ophthalmology · 2022Article
- Clinical characteristics and efficacy of methotrexate in Japanese patients with noninfectious scleritis.Japanese journal of ophthalmology · 2021Article
- Scleritis: Differentiating infectious from non-infectious entities.Indian journal of ophthalmology · 2020Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThis study evaluated the performance of a standardized grading system for scleritis using standard digital photographs.
designCross-sectional interobserver agreement study.
participantsPhoto archives from the National Eye Institute.
methodsThree uveitis specialists from 3 different centers graded 79 randomly arranged images of the sclera with various degrees of inflammation. Grading was done using standard screen resolution (1024×768 pixels) on a 0 to 4+ scale in 2 sessions: (1) without using reference photographs and (2) with reference to a set of standard photographs (proposed grading system). The graders were masked to the order of images, and the order of images was randomized. Interobserver agreement in grading the severity of inflammation with and without the use of grading system was evaluated.
main outcome measuresInterobserver agreement.
resultsThe proposed grading system for assessing activity in scleritis demonstrated a good interobserver agreement. Interobserver agreement (pooled κ) was poor (0.289) without photographic guidance and improved substantially when the "grading system" with standardized photographs was used (κ = 0.603).
conclusionsThis system of standardized images for scleritis grading provides significantly more consistent grading of scleral inflammation in this study and has clear applications in clinical settings and clinical research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.