Trial reportJournal of electrocardiology
A new electrocardiogram marker to identify patients at low risk for ventricular tachyarrhythmias: sum magnitude of the absolute QRST integral.
Trial report in Journal of electrocardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Novel measure of electrical dyssynchrony predicts response in cardiac resynchronization therapy: Results from the SMART-AV Trial.Heart rhythm · 2015Trial
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- Electrical Heterogeneity in Hispanic Background Subpopulations: The HCHS/SOL.JACC. Advances · 2024Article
- Spatial Ventricular Gradient: A Measure of Global Electrical Heterogeneity.JACC. Advances · 2023Article
- Competing risks in patients with primary prevention implantable cardioverter-defibrillators: Global Electrical Heterogeneity and Clinical Outcomes study.Heart rhythm · 2021Article
- Electrocardiogram machine learning for detection of cardiovascular disease in African Americans: the Jackson Heart Study.European heart journal. Digital health · 2021Article
- Article
- Global electrical heterogeneity associated with drug-induced torsades de pointes.Heart rhythm · 2021Article
- Changes in global electrical heterogeneity associated with dofetilide, quinidine, ranolazine, and verapamil.Heart rhythm · 2020Article
- Bringing Critical Race Praxis Into the Study of Electrophysiological Substrate of Sudden Cardiac Death: The ARIC Study.Journal of the American Heart Association · 2020Article
- Dynamic predictive accuracy of electrocardiographic biomarkers of sudden cardiac death within a survival framework: the Atherosclerosis Risk in Communities (ARIC) study.BMC cardiovascular disorders · 2019Article
- Vectorcardiogram in athletes: The Sun Valley Ski Study.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019Article
- Importance of the heart vector origin point definition for an ECG analysis: The Atherosclerosis Risk in Communities (ARIC) study.Computers in biology and medicine · 2019Article
- The Reproducibility of Global Electrical Heterogeneity ECG Measurements.Computing in cardiology · 2018Article
- Global Electrical Heterogeneity: Mechanisms and Clinical Significance.Computing in cardiology · 2018Article
- A Multi-Scale Investigation of Global Electrical Heterogeneity: Effects of Body Habitus, Respiration, and Tissue Conductivity.Computing in cardiology · 2018Article
- Improving sudden cardiac death risk stratification by evaluating electrocardiographic measures of global electrical heterogeneity and clinical outcomes among patients with implantable cardioverter-defibrillators: rationale and design for a retrospective, multicenter, cohort study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2018Article
- Genome-Wide Associations of Global Electrical Heterogeneity ECG Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study).Journal of the American Heart Association · 2018Article
- Global ECG Measures and Cardiac Structure and Function: The ARIC Study (Atherosclerosis Risk in Communities).Circulation. Arrhythmia and electrophysiology · 2018Article
- Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWe proposed and tested a novel electrocardiogram marker of risk of ventricular arrhythmias (VAs).
methodsDigital orthogonal electrocardiograms were recorded at rest before implantable cardioverter-defibrillator (ICD) implantation in 508 participants of a primary prevention ICDs prospective cohort study (mean ± SD age, 60 ± 12 years; 377 male [74%]). The sum magnitude of the absolute QRST integral in 3 orthogonal leads (SAI QRST) was calculated. A derivation cohort of 128 patients was used to define a cutoff; a validation cohort (n = 380) was used to test a predictive value.
resultsDuring a mean follow-up of 18 months, 58 patients received appropriate ICD therapies. The SAI QRST was lower in patients with VA (105.2 ± 60.1 vs 138.4 ± 85.7 mV ms, P = .002). In the Cox proportional hazards analysis, patients with SAI QRST not exceeding 145 mV ms had about 4-fold higher risk of VA (hazard ratio, 3.6; 95% confidence interval, 1.96-6.71; P < .0001) and a 6-fold higher risk of monomorphic ventricular tachycardia (hazard ratio, 6.58; 95% confidence interval, 1.46-29.69; P = .014), whereas prediction of polymorphic ventricular tachycardia or ventricular fibrillation did not reach statistical significance.
conclusionHigh SAI QRST is associated with low risk of sustained VA in patients with structural heart disease.
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