ArticleBiological psychiatry2011
Mirtazapine alters cue-associated methamphetamine seeking in rats.
Article in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Attenuation of cue-induced heroin-seeking by the atypical antidepressant mirtazapine.Drug and alcohol dependence reports · 2026Article
- Pharmacological Treatments for Methamphetamine Use Disorder: Current Status and Future Targets.Substance abuse and rehabilitation · 2024Review
- Mirtazapine decreased cocaine-inducedFrontiers in psychiatry · 2024Article
- Isradipine, an L-type calcium channel inhibitor, attenuates cue-associated methamphetamine-seeking in mice.Brain research · 2023Article
- Acute and protracted abstinence from methamphetamine bidirectionally changes intrinsic excitability of indirect pathway spiny projection neurons in the dorsomedial striatum.Scientific reports · 2022Article
- Comparison of prefrontal cortex sucrose seeking ensembles engaged in multiple seeking sessions: Context is key.Journal of neuroscience research · 2022Article
- Mitochondrial function influences expression of methamphetamine-induced behavioral sensitization.Scientific reports · 2021Article
- Gut and brain profiles that resemble pre-motor and early-stage Parkinson's disease in methamphetamine self-administering rats.Drug and alcohol dependence · 2021Article
- Article
- Mirtazapine and ketanserin alter preference for gambling-like schedules of reinforcement in rats.Progress in neuro-psychopharmacology & biological psychiatry · 2017Article
- Pharmacologically distinct pramipexole-mediated akinesia vs. risk-taking in a rat model of Parkinson's disease.Progress in neuro-psychopharmacology & biological psychiatry · 2016Article
- Cocaine self-administration enhances excitatory responses of pyramidal neurons in the rat medial prefrontal cortex to human immunodeficiency virus-1 Tat.The European journal of neuroscience · 2015Article
- Methamphetamine decreases CD4 T cell frequency and alters pro-inflammatory cytokine production in a model of drug abuse.European journal of pharmacology · 2015Article
- Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism.Neuropharmacology · 2015Article
- Role of cues and contexts on drug-seeking behaviour.British journal of pharmacology · 2014Review
- Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats.Pharmacology, biochemistry, and behavior · 2014Article
- Using conditioned place preference to identify relapse prevention medications.Neuroscience and biobehavioral reviews · 2013Review
- The group II metabotropic glutamate receptor agonist, LY379268, decreases methamphetamine self-administration in rats.Drug and alcohol dependence · 2013Article
- Mirtazapine, and mirtazapine-like compounds as possible pharmacotherapy for substance abuse disorders: evidence from the bench and the bedside.Pharmacology & therapeutics · 2012Review
- The atypical antidepressant mirtazapine attenuates expression of morphine-induced place preference and motor sensitization.Brain research · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMethamphetamine (METH) is a potent psychostimulant, repeated use of which can result in a substance abuse disorder. Withdrawn individuals are highly prone to relapse, which may be driven, at least in part, by a hyperresponsivity to METH-associated cues that can prompt METH-seeking. Clinically efficacious pharmacotherapies for METH abuse are critically needed. Mirtazapine (Remeron) is an atypical antidepressant that antagonizes activated norepinephrine(α)₂, histamine₁ serotonin (5-HT)₂(A/C), and 5-HT₃ receptors. This pharmacologic profile prompted our interest in its potential for preventing relapse to METH-taking. This study tested the hypothesis that mirtazapine would attenuate METH-seeking in rats trained to self-administer METH.
methodsRats were trained to self-administer METH in a lever-pressing operant task. The effect of mirtazapine on METH-seeking was determined by evaluating lever pressing in the presence of cues previously associated with METH, but in the absence of METH reinforcement. Two paradigms were used: cue reactivity, wherein rats do not undergo extinction training, and a cue-induced reinstatement paradigm after extinction.
resultsMirtazapine (5.0 mg/kg) pretreatment reduced METH-seeking by ∼ 50% in the first 15 min of cue reactivity and cue-induced reinstatement testing. This mirtazapine dose did not significantly affect motor performance.
conclusionsThis study revealed the overlapping nature of cue reactivity and cue-induced reinstatement procedures and provided preclinical evidence that mirtazapine can attenuate METH-seeking behavior.
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